发明申请
- 专利标题： DNA Damage Repair Inhibitors for the Treatment of Cancer
- 专利标题（中）： DNA损伤修复抑制剂治疗癌症
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申请号： US13286475申请日： 2011-11-01
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公开(公告)号： US20120135983A1公开(公告)日： 2012-05-31
- 发明人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
- 申请人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
- 专利权人： The Institute of Cancer Reseach,Kudos Pharmaceuticals Limited,Royal Cancer Hospital
- 当前专利权人： The Institute of Cancer Reseach,Kudos Pharmaceuticals Limited,Royal Cancer Hospital
- 优先权： GB0327844.7 20031201
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61P35/00 ; G01N33/566 ; C12Q1/06 ; A61K31/502 ; C12Q1/68
摘要：
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
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