发明申请
US20120136033A1 Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof
审中-公开
磷脂酰肌醇-3,4,5-三磷酸（PIP3）的小分子拮抗剂及其用途
- 专利标题： Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof
- 专利标题（中）： 磷脂酰肌醇-3,4,5-三磷酸（PIP3）的小分子拮抗剂及其用途
-
申请号： US13321293申请日： 2010-05-17
-
公开(公告)号： US20120136033A1公开(公告)日： 2012-05-31
- 发明人: Alexei Degterev , Mikhail Reibarkh , Gerhard Wagner , Junying Yuan
- 申请人： Alexei Degterev , Mikhail Reibarkh , Gerhard Wagner , Junying Yuan
- 申请人地址： US MA Cambridge US MA Boston
- 专利权人： President and Fellows of Harvard College,Tufts University
- 当前专利权人： President and Fellows of Harvard College,Tufts University
- 当前专利权人地址： US MA Cambridge US MA Boston
- 国际申请： PCT/US10/01452 WO 20100517
- 主分类号： A61K31/426
- IPC分类号： A61K31/426 ; A61P35/00 ; C12N5/071 ; A61K31/17 ; B82Y5/00
摘要：
Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.
信息查询
IPC分类:
