发明申请
- 专利标题： ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF
- 专利标题（中）： 用于诱导蚜虫的蒽醌提取物及其制备方法
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申请号： US13398368申请日： 2012-02-16
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公开(公告)号： US20120141524A1公开(公告)日： 2012-06-07
- 发明人: Yang-Chang Wu , Mei-Chin Lu , Fang-Rong Chang , Ying-Chi Du , Tung-Ying Wu
- 申请人： Yang-Chang Wu , Mei-Chin Lu , Fang-Rong Chang , Ying-Chi Du , Tung-Ying Wu
- 申请人地址： TW Kaohsiung City
- 专利权人： KAOHSIUNG MEDICAL UNIVERSITY
- 当前专利权人： KAOHSIUNG MEDICAL UNIVERSITY
- 当前专利权人地址： TW Kaohsiung City
- 优先权： TW098104772 20090213
- 主分类号： A61K36/07
- IPC分类号： A61K36/07 ; A61P35/02 ; G01N30/00 ; A61K31/575
摘要：
A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A. camphorata (AC); (b) extracting the fruiting bodies with a first ethanol solution; and (c) obtaining EEAC. EEAC further can be sequentially extracted or fractioned by n-hexane, ethyl acetate and ethanol, and an n-hexane fraction (FC), an ethyl acetate fraction (FA) and an ethanol fraction (FB) respectively are generated. The growth inhibition and apoptosis induction of leukemia cell line HL 60 are effectively mediated by FA product, in which zhankuic acid A is the bioactive marker. The amount of triterpenoid in the fruiting body of AC can be determined by NMR and HPLC analysis.
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