发明申请
US20120142707A1 MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS
有权
作为HIV成熟抑制剂的改性的C-3白蛋白酸衍生物
- 专利标题： MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS
- 专利标题（中）： 作为HIV成熟抑制剂的改性的C-3白蛋白酸衍生物
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申请号： US13151706申请日： 2011-06-02
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公开(公告)号： US20120142707A1公开(公告)日： 2012-06-07
- 发明人: Alicia Regueiro-Ren , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen
- 申请人： Alicia Regueiro-Ren , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： A61K31/235
- IPC分类号： A61K31/235 ; C07C63/66 ; C07D257/04 ; C07D215/50 ; C07D333/40 ; C07D213/64 ; C07D239/28 ; A61K31/194 ; A61K31/196 ; A61K31/41 ; A61K31/47 ; A61K31/381 ; A61K31/4418 ; A61K31/505 ; A61P31/12 ; A61P31/18 ; A61P37/02 ; C07C309/65 ; C07C69/753
摘要：
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural products derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
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