A liquid filter assembly is provided. The assembly includes a liquid filter cartridge and a housing. The liquid filter cartridge, includes, among other things, first and second, opposite, end caps each having a central aperture therethrough. A seal arrangement including a radially directed seal is mounted on a seal support of the first end cap that projects away from the second end cap. The cartridge includes a seal mount configured to define a seal plane non-orthogonal to a central axis of the cartridge. The housing includes a filter head and a housing sidewall. The filter head includes a filter head having a body, a top cover and a bottom aperture opposite the top cover. The housing extends through the bottom aperture. The cartridge as described is installed in the housing, with an end cap radially sealed against a tube in a bottom of the housing.