Invention Application
US20120148538A1 COMPOSITION FOR HARD TISSUE FORMATION AND, DENTIN OR PULP REGENERATION CONTAINING AMELOBLAST, APICAL BUD CELL OR ITS CULTURE FLUID AS AN ACTIVE INGREDIENT
审中-公开
用于硬组织形成的组合物，含有AMELOBLAST，生物体细胞或其文化液体的丹宁或脉冲再生作为活性成分
- Patent Title: COMPOSITION FOR HARD TISSUE FORMATION AND, DENTIN OR PULP REGENERATION CONTAINING AMELOBLAST, APICAL BUD CELL OR ITS CULTURE FLUID AS AN ACTIVE INGREDIENT
- Patent Title (中): 用于硬组织形成的组合物，含有AMELOBLAST，生物体细胞或其文化液体的丹宁或脉冲再生作为活性成分
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Application No.: US13182011Application Date: 2011-07-13
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Publication No.: US20120148538A1Publication Date: 2012-06-14
- Inventor: Joo-Cheol PARK , Won-Jun SHON , Jihyun LEE
- Applicant: Joo-Cheol PARK , Won-Jun SHON , Jihyun LEE
- Applicant Address: KR Seoul
- Assignee: SNU R&DB FOUNDATION
- Current Assignee: SNU R&DB FOUNDATION
- Current Assignee Address: KR Seoul
- Priority: KRKR10-2010-0127022 20101213; KRKR10-2011-0069292 20110713
- Main IPC: A61K35/32
- IPC: A61K35/32 ; A61P19/08 ; C12N5/071
Abstract:
The present invention relates to a composition for hard tissue formation and dentin, or dental pulp regeneration comprising ameloblasts, apical bud cells, or its culture fluid as an active ingredient. The ameloblasts, apical bud cells, or its culture fluid promotes the differentiation of odontoblasts, human dental pulp stem cells and osteoblasts, increases DSPP promoter activity, induces dental pulp regeneration of dental pulp stem cells, and induces hard tissue formation significantly in vivo, so that they can be effectively used for a composition for promoting hard tissue formation and dentin or dental pulp regeneration.
Information query
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