发明申请
- 专利标题: DIHYDROPYRIMIDINE COMPOUNDS AND PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
- 专利标题(中): 二氢嘧啶化合物及其制备方法,药物组合物及其用途
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申请号: US13380270申请日: 2010-05-27
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公开(公告)号: US20120149695A1公开(公告)日: 2012-06-14
- 发明人: Song Li , Xiaoqian Xu , Guoming Zhao , Lili Wang , Hua Guan , Junhai Xiao , Wu Zhong , Zhibing Zheng , Yunde Xie , Xingzhou Li , Xiaokui Wang , Xinbo Zhou , Hongying Liu
- 申请人: Song Li , Xiaoqian Xu , Guoming Zhao , Lili Wang , Hua Guan , Junhai Xiao , Wu Zhong , Zhibing Zheng , Yunde Xie , Xingzhou Li , Xiaokui Wang , Xinbo Zhou , Hongying Liu
- 申请人地址: CN Beijing
- 专利权人: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A.
- 当前专利权人: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A.
- 当前专利权人地址: CN Beijing
- 优先权: CN200910148630.2 20090625
- 国际申请: PCT/CN2010/000757 WO 20100527
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; C07D403/06 ; C07D401/06 ; C07D413/06 ; A61K31/5377 ; A61P31/20 ; A61K31/541 ; C07D401/14 ; C07D413/14 ; C07D403/14 ; A61P31/12 ; A61K31/506 ; C07D239/20 ; C07D417/06
摘要:
Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.