A method and system for communication between audio/video (AV) devices. In one embodiment communication between AV devices includes establishing an AV path stream for AV data streaming between a source AV device and a destination AV device, wherein each AV device includes one or more I/O ports for connecting the AV device to another AV device via a communication link including multiple communication lanes. Asynchronous and isochronous AV data is multiplexed for transmission via one or more fixed length data cells, each data cell capable of carrying one or more of: an asynchronous data symbol and an isochronous data symbol. Multiplexing includes selectively mapping asynchronous data onto isochronous symbols for transmission during a video blanking period. One or more data cells are transmitted from a physical layer of the source AV device to the destination AV device, via one or more communication lanes.