Methods are disclosed for supporting stereo 3D video in computing devices. A computing device can receive stereo 3D video data employing a YUV color space and chroma subsampling, and can generate anaglyph video data therefrom. The anaglyph video data can be generated by unpacking the stereo 3D video data to left and right views and combining the left and right views into a single view via matrix transformation. The combining uses transform matrices that correspond to a video pipeline configuration. The transform matrix coefficients can depend on characteristics of the video pipeline components. Modified transform matrix coefficients can be used in response to changes in the video pipeline configuration. Video encoded in stereo 3D video data can be selected to be displayed in stereo 3D, anaglyph or monoscopic form, depending on user input and/or characteristics of video pipeline components.