- 专利标题: NOVEL ANTI-IL13 ANTIBODIES AND USES THEREOF
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申请号: US13275684申请日: 2011-10-18
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公开(公告)号: US20120156203A1公开(公告)日: 2012-06-21
- 发明人: Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- 申请人: Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61P11/00 ; A61P29/00
摘要:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
公开/授权文献
- US08734801B2 Anti-IL13 antibodies and uses thereof 公开/授权日:2014-05-27
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