发明申请
US20120156260A1 Prodrugs Containing an Aromatic Amine Connected By an Amido Bond to a Linker
有权
含有通过酰胺键与连接体连接的芳香胺的前药
- 专利标题： Prodrugs Containing an Aromatic Amine Connected By an Amido Bond to a Linker
- 专利标题（中）： 含有通过酰胺键与连接体连接的芳香胺的前药
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申请号： US13387981申请日： 2010-07-30
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公开(公告)号： US20120156260A1公开(公告)日： 2012-06-21
- 发明人: Harald Rau , Julia Baron , Ulrich Hersel , Mathias Krusch
- 申请人： Harald Rau , Julia Baron , Ulrich Hersel , Mathias Krusch
- 申请人地址： DK Hellerup
- 专利权人： ASCENDIS PHARMA A/S
- 当前专利权人： ASCENDIS PHARMA A/S
- 当前专利权人地址： DK Hellerup
- 优先权： EP09167029.9 20090731
- 国际申请： PCT/EP2010/061163 WO 20100730
- 主分类号： A61K31/428
- IPC分类号： A61K31/428 ; A61K9/14 ; A61P25/24 ; A61P25/00 ; A61P25/18 ; C07D277/60 ; A61P25/16
摘要：
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising a drug linker conjugate D-L, wherein an aromatic amine containing biologically active moiety is connected (bound) by an amido bound to a linker. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
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