A pick and place system including at least one input conveyor, at least one output conveyor, at least one pick and place robot and control circuitry. Available picking positions on an input conveyor at which a respective item can be picked are determined as well as available placing positions on an output conveyor at which a respective item can be placed. For the available picking positions and the available placing positions, a respective picking time and placing time is calculated, and the at least one robot is instructed to pick items at the picking positions and place the items at the placing positions in an order determined by the respective picking times and placing times.