发明申请
- 专利标题： COMPOSITIONS AND METHODS RELATING TO NON-HUMAN ANIMALS MODIFIED TO PROMOTE PRODUCTION OF SELECTED GAMETES
- 专利标题（中）： 与促进选择游戏生产有关的非人类动物相关的组合物和方法
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申请号： US13337892申请日： 2011-12-27
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公开(公告)号： US20120167242A1公开(公告)日： 2012-06-28
- 发明人: Michael V. Wiles , Robert Taft
- 申请人： Michael V. Wiles , Robert Taft
- 申请人地址： US ME Bar Harbor
- 专利权人： The Jackson Laboratory
- 当前专利权人： The Jackson Laboratory
- 当前专利权人地址： US ME Bar Harbor
- 主分类号： C12N15/877
- IPC分类号： C12N15/877 ; C12N5/10
摘要：
Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present invention. Methods of generating a non-human embryo and/or animal derived from donor stem cells, methods of generating chimeric non-human animals having substantially all gametes and/or germ cells derived from the donor stem cells, methods of producing a non-human host embryo lacking functional endogenous germ cells and non-human host embryos incapable of developing endogenous gametes of the present invention are described herein.
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