公开(公告)号：US20240288445A1

公开(公告)日：2024-08-29

申请号：US18603889

申请日：2024-03-13

申请人： The Jackson Laboratory

发明人： James Keck ,  Chunting Ye

IPC分类号： G01N33/68 ,  A01K67/0278 ,  C07K16/28

CPC分类号： G01N33/6863 ,  A01K67/0278 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2887 ,  C07K16/2893 ,  A01K2227/105 ,  A01K2267/0325

摘要： Humanized mouse models and methods are provided for determining whether administration of an immunomodulatory drug likely elicits a severe cytokine release syndrome in a human. Humanized mouse models and methods are also provided for determining the immunotoxicity in a human of a drug candidate or of drug combinations.

公开(公告)号：US20240238616A1

公开(公告)日：2024-07-18

申请号：US18563207

申请日：2022-05-26

申请人： THE JACKSON LABORATORY

发明人： Roel VERHAAK

IPC分类号： A61N5/10

CPC分类号： A61N5/1001 ,  A61N5/1077 ,  A61N2005/1024 ,  A61N2005/1098

摘要： The invention relates, in part, to methods and compounds for radiosensitizing cells and increasing efficacy of treatments for cancers.

公开(公告)号：US20240141411A1

公开(公告)日：2024-05-02

申请号：US18280198

申请日：2022-03-03

申请人： The Jackson Laboratory

发明人： Albert Cheng ,  Zukai Liu

IPC分类号： C12Q1/6816 ,  C12N9/22 ,  C12N15/115

CPC分类号： C12Q1/6816 ,  C12N9/22 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/20 ,  C12Y301/00

摘要： Provided herein, in some aspects, is a multiplex RNA targeting system that enables live cell imaging and/or modification of multiple RNA targets. Specifically, the disclosure provides a method of live cell imaging of ribonucleic acid (RNA), or targeting RNA in a live cell, comprising: (a) delivering to a cell an RNA-editing complex that comprises a catalytically inactive Cas13 (dCas13) nuclease, a Cas 13 guide RNA (gRNA) comprising an RNA aptamer sequence, and a detectable molecule linked to an RNA-binding domain (RBD), or an RNA effector molecule linked to an RBD sequence that specifically binds to the RNA aptamer sequence; and (b) imaging the detectable molecule or RNA aptamer and RBD binding.

公开(公告)号：US20240068042A1

公开(公告)日：2024-02-29

申请号：US18272260

申请日：2022-01-10

申请人： The Jackson Laboratory

发明人： Edison T. Liu ,  Francesca Menghi

IPC分类号： C12Q1/6886 ,  C12Q1/6869

CPC分类号： C12Q1/6886 ,  C12Q1/6869 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

摘要： Provided herein, in some embodiments, are novel methods for predicting response to a platinum-based chemotherapeutic agent in triple negative breast cancer and ovarian carcinoma.

公开(公告)号：US20240041011A1

公开(公告)日：2024-02-08

申请号：US18265521

申请日：2021-12-06

申请人： The Jackson Laboratory

发明人： James Keck

IPC分类号： A01K67/027 ,  C12N5/071 ,  C12N5/09

CPC分类号： A01K67/0271 ,  C12N5/0688 ,  C12N5/0693 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/0337

摘要： Provided herein are immnunodeficient mouse models engrafted with cells comprising a pathogen entry moiety, for example, for assessing pathogenic infection. The pathogen may be a virus, such as a respiratory virus.

公开(公告)号：US20240010970A1

公开(公告)日：2024-01-11

申请号：US18032845

申请日：2021-10-20

申请人： The Jackson Laboratory

发明人： Julia Oh

IPC分类号： C12N1/20 ,  A61K38/17 ,  A61P31/00 ,  G01N33/569

CPC分类号： C12N1/20 ,  A61K38/1729 ,  A61P31/00 ,  G01N33/569 ,  G01N2800/26

摘要： Provided herein are antimicrobial biosensors for skin for treating Staphylococcus aureus Type I, Type II, Type III, and/or Type IV infection. In some embodiments, the antimicrobial biosensors are expressed in Staphylococcus epidermidis cells.

公开(公告)号：US20230374608A1

公开(公告)日：2023-11-23

申请号：US18302737

申请日：2023-04-18

申请人： The Jackson Laboratory

发明人： Jacques Banchereau ,  Diogo Fremando Troggian Veiga ,  Anne Deslattes Mays ,  Saman Zeeshan ,  Anna Karolina Palucka

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Provided herein, in some embodiments, are methods, compositions, and systems for identifying alternatively spliced tumor-specific exon inclusion and exclusion events that can be used for survival prognosis.

公开(公告)号：US20230309827A1

公开(公告)日：2023-10-05

申请号：US17969102

申请日：2022-10-19

申请人： The Jackson Laboratory ,  Purdue Research Foundation

发明人： Pedro P. Irazoqui ,  Dohyuk Ha ,  William J. Chappell ,  Simon W.M. John

IPC分类号： A61B3/16 ,  A61B5/00

CPC分类号： A61B3/16 ,  A61B5/686 ,  A61B5/0215

摘要： Certain pressure sensor devices are much smaller than prior art devices, yet are at least as sensitive as the prior art devices. A capacitive pressure sensor can include a flexible substrate that permits bending of a pressure sensing region without significantly affecting operation thereof. The pressure sensor can include a flexible membrane in which an electrode is sandwiched between two layers of polymeric material. The sandwiched electrode can be extremely close to a reference electrode so as to provide for highly sensitive capacitance readings, yet the membrane can be restricted from contacting the reference electrode under high pressure condition.

公开(公告)号：US20230295615A1

公开(公告)日：2023-09-21

申请号：US18040939

申请日：2021-08-06

申请人： The Jackson Laboratory

发明人： Albert Cheng ,  Nathaniel Jillette

IPC分类号： C12N15/11 ,  C12N9/12 ,  C12N9/22

CPC分类号： C12N15/11 ,  C12N9/1276 ,  C12N9/22 ,  C12N2310/20

摘要： The invention described herein provides compositions and reagents for integrating large sequences (e.g., 150 bp or more) into a selected target DNA sequence via prime editing.

公开(公告)号：US11466307B2

公开(公告)日：2022-10-11

申请号：US15934465

申请日：2018-03-23

申请人： The Jackson Laboratory

发明人： Yijun Ruan ,  Meizhen Zheng ,  Junhong Oscar Luo

IPC分类号： C12Q1/6809 ,  C12Q1/6806

摘要： The invention described herein provides reagents (e.g., kits), compositions, and methods for carrying out an unbiased genome-wide strategy to identify the functional targets for all ncRNAs.