A method, system and computer-usable medium are disclosed for managing prefetch streams in a virtual machine environment. Compiled application code in a first core, which comprises a Special Purpose Register (SPR) and a plurality of first prefetch engines, initiates a prefetch stream request. If the prefetch stream request cannot be initiated due to unavailability of a first prefetch engine, then an indicator bit indicating a Prefetch Stream Dispatch Fault is set in the SPR, causing a Hypervisor to interrupt the execution of the prefetch stream request. The Hypervisor then calls its associated operating system (OS), which determines prefetch engine availability for a second core comprising a plurality of second prefetch engines. If a second prefetch engine is available, then the OS migrates the prefetch stream request from the first core to the second core, where it is initiated on an available second prefetch engine.