发明申请
- 专利标题： GLYCINE COMPOUND
- 专利标题（中）： 甘氨酸化合物
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申请号： US13394505申请日： 2010-09-15
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公开(公告)号： US20120184520A1公开(公告)日： 2012-07-19
- 发明人: Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Yuji Koga , Norio Seki , Jiro Fujiyasu , Masahiro Neya
- 申请人： Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Yuji Koga , Norio Seki , Jiro Fujiyasu , Masahiro Neya
- 申请人地址： JP Tokyo
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2009-214991 20090916
- 国际申请： PCT/JP2010/065918 WO 20100915
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C07D401/14 ; A61K31/4545 ; C07D403/14 ; C07C237/06 ; A61K31/167 ; C07C275/40 ; A61K31/17 ; C07D309/06 ; A61K31/351 ; A61K31/24 ; C07D213/82 ; A61K31/455 ; C07D413/12 ; A61K31/5377 ; C07D413/14 ; C07D401/12 ; C07D413/04 ; A61K31/551 ; C07D295/215 ; A61K31/495 ; C07D417/04 ; A61K31/541 ; C07D223/04 ; A61K31/55 ; C07D223/12 ; C07D267/10 ; A61K31/553 ; A61P3/10 ; A61P9/12 ; A61P29/00 ; A61P19/06 ; A61P19/02 ; A61P17/02 ; A61P25/28 ; A61P9/10 ; A61P11/06 ; A61P11/00 ; A61P1/00 ; A61P17/00 ; A61P17/06 ; A61P9/00 ; A61P1/16 ; C07D403/04
摘要：
[Problem]The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases.[Means for Solution]The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that a compound of the present invention or a salt thereof exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. The present invention further relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound of the present invention or a salt thereof, and an excipient.
公开/授权文献
- US08802679B2 Glycine compound 公开/授权日：2014-08-12
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