发明申请
US20120196803A1 FUSION PROTEINS FOR DELIVERY OF GDNF AND BDNF TO THE CENTRAL NERVOUS SYSTEM
审中-公开
用于将GDNF和BDNF递送至中央神经系统的融合蛋白
- 专利标题： FUSION PROTEINS FOR DELIVERY OF GDNF AND BDNF TO THE CENTRAL NERVOUS SYSTEM
- 专利标题（中）： 用于将GDNF和BDNF递送至中央神经系统的融合蛋白
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申请号： US13377480申请日： 2010-06-11
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公开(公告)号： US20120196803A1公开(公告)日： 2012-08-02
- 发明人: Michel Demeule , Dominique Boivin , Jean-Paul Castaigne
- 申请人： Michel Demeule , Dominique Boivin , Jean-Paul Castaigne
- 申请人地址： CA Montreal
- 专利权人： ANGIOCHEM INC.
- 当前专利权人： ANGIOCHEM INC.
- 当前专利权人地址： CA Montreal
- 国际申请： PCT/CA2010/000889 WO 20100611
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; C12N15/62 ; C12N15/63 ; A61P25/28 ; A61P25/00 ; A61P25/24 ; A61P25/18 ; C07K19/00 ; C12P21/02
摘要：
The present invention relates to a compound that includes a peptide vector, such as angiopep-2 which acts as a carrier across the blood-brain barrier, linked to glial-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), or a related molecule, such as an analog or a fragment thereof. The compounds of the invention may be used to treat any disease where increased neuronal survival or growth is desired, e.g., neurodegenerative diseases, such as Parkinson's disease or amyotrophic lateral sclerosis. Other diseases can be treated using the compounds include schizophrenia and depression.
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