公开(公告)号：US20120196803A1

公开(公告)日：2012-08-02

申请号：US13377480

申请日：2010-06-11

申请人： Michel Demeule ,  Dominique Boivin ,  Jean-Paul Castaigne

发明人： Michel Demeule ,  Dominique Boivin ,  Jean-Paul Castaigne

IPC分类号： A61K38/18 ,  C12N15/62 ,  C12N15/63 ,  A61P25/28 ,  A61P25/00 ,  A61P25/24 ,  A61P25/18 ,  C07K19/00 ,  C12P21/02

CPC分类号： C07K14/4756 ,  A61K38/00 ,  A61K47/64 ,  C07K14/48 ,  C07K2319/03

摘要： The present invention relates to a compound that includes a peptide vector, such as angiopep-2 which acts as a carrier across the blood-brain barrier, linked to glial-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), or a related molecule, such as an analog or a fragment thereof. The compounds of the invention may be used to treat any disease where increased neuronal survival or growth is desired, e.g., neurodegenerative diseases, such as Parkinson's disease or amyotrophic lateral sclerosis. Other diseases can be treated using the compounds include schizophrenia and depression.

摘要翻译： 本发明涉及一种化合物，其包含肽载体，例如作用于血脑屏障的载体的血管紧张素-2，与神经胶质来源的神经营养因子（GDNF），脑源性神经营养因子（BDNF）， 或相关分子，例如其类似物或片段。 本发明的化合物可用于治疗需要增加神经元存活或生长的任何疾病，例如神经变性疾病，例如帕金森病或肌萎缩性侧索硬化症。 可以使用包括精神分裂症和抑郁症在内的化合物治疗其他疾病。

公开(公告)号：US20110288009A1

公开(公告)日：2011-11-24

申请号：US13132838

申请日：2009-12-07

申请人： Jean-Paul Castaigne ,  Michel Demeule ,  Dominique Boivin ,  Betty Lawrence ,  Christian Che

发明人： Jean-Paul Castaigne ,  Michel Demeule ,  Dominique Boivin ,  Betty Lawrence ,  Christian Che

IPC分类号： A61K38/22 ,  C07K19/00 ,  C07H21/00 ,  A61P3/04 ,  A61P9/12 ,  A61P3/06 ,  A61P3/00 ,  A61P3/08 ,  A61P9/00 ,  C07K14/575 ,  A61P3/10

CPC分类号： C07K14/5759 ,  A61K38/00 ,  A61K47/64 ,  C07K14/8117 ,  C07K2319/10

摘要： The present invention features a compound having the formula A-X-B, where A is peptide vector capable of enhancing transport of the compound across the blood-brain barrier or into particular cell types, X is a linker, and B is a leptin, a leptin analog, or OB receptor agonist. The compounds of the invention can be used to treat any disease in which increased amounts of leptin are desired, such as metabolic diseases including obesity and diabetes.

摘要翻译： 本发明的特征在于具有式AXB的化合物，其中A是能够增强化合物穿过血脑屏障或特定细胞类型的转运的肽载体，X是接头，B是瘦蛋白，瘦蛋白类似物， 或OB受体激动剂。 本发明的化合物可用于治疗任何需要增加瘦素量的疾病，例如包括肥胖症和糖尿病在内的代谢疾病。

公开(公告)号：US10443859B2

公开(公告)日：2019-10-15

申请号：US15543870

申请日：2015-03-25

申请人： Dominique Boivin

发明人： Dominique Boivin

IPC分类号： F24D17/00 ,  F24H1/20 ,  F24D19/10 ,  F24H9/12 ,  F28D20/00

摘要： A water heating assembly, related kit, use and method make use of a temperature control near a point of use of water, so as to reduce a time response for hot water at this point of use are provided. The water heating assembly includes a tank for containing water, an inlet temperature sensor for sensing an inlet temperature of the water upstream of the tank, and a valve located upstream of the tank. The valve is actuated when the sensed inlet temperature reaches a given temperature set-point such that the water is bypassed from the tank and directly sent to the point of use. The water heating assembly is configured such that the point of use can be fed with water at the desired temperature in a reduced time, the water coming directly from the hot water source and/or the water heating assembly, thereby saving water, energy and time.