发明申请
US20120196927A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR METABOLIC SYNDROME
审中-公开
用于代谢综合征的预防和/或治疗药物
- 专利标题: PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR METABOLIC SYNDROME
- 专利标题(中): 用于代谢综合征的预防和/或治疗药物
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申请号: US13296356申请日: 2011-11-15
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公开(公告)号: US20120196927A1公开(公告)日: 2012-08-02
- 发明人: Young-Sil Lee , Byung-Yoon Cha , Xiao-Xing Wang , Sun-Sil Choi , Bong-Keun Choi , Hiroshi Yamakawa , Kiyoto Saito , Takayuki Yonezawa , Toshiaki Teruya , Kazuo Nagai , Je-Tae Woo
- 申请人: Young-Sil Lee , Byung-Yoon Cha , Xiao-Xing Wang , Sun-Sil Choi , Bong-Keun Choi , Hiroshi Yamakawa , Kiyoto Saito , Takayuki Yonezawa , Toshiaki Teruya , Kazuo Nagai , Je-Tae Woo
- 申请人地址: JP Tokyo
- 专利权人: ERINA CO., INC.
- 当前专利权人: ERINA CO., INC.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2009-123896 20090522
- 主分类号: A61K31/353
- IPC分类号: A61K31/353 ; C12Q1/68 ; G01N21/64 ; A61P3/00
摘要:
A method for screening a substance for treating visceral adiposity syndrome comprises: (1) extracting a total RNA fraction from skeletal muscle collected from non-human mammals of a group to which a predetermined amount of the test substance has been administered and from non-human mammals of a group to which the test substance has not been administered; (2) quantifying the expression quantity of mRNA in the total RNA fraction extracted that encodes a glucose transporter gene by a specific method; and (3) comparing and analyzing the quantity of the test substance ingested, the body weight gain, and the expression quantity of RNA encoding the glucose transporter gene during the administration period for the non-human mammals of the test substance-administered group to these quantities for the non-human mammals that constitute the test substance-unadministered group to thereby determine the effect of the test substance on the metabolic syndrome.