Invention Application
- Patent Title: MULTIFUNCTIONAL ANTIBODY CONJUGATES
- Patent Title (中): 多功能抗体结合
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Application No.: US13305354Application Date: 2011-11-28
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Publication No.: US20120201809A1Publication Date: 2012-08-09
- Inventor: Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
- Applicant: Abhijit Suresh Bhat , Curt William Bradshaw , Olivier Alexandre Laurent , Alice Lee , Richard Ryan Preston , David Tumelty , Lauren Diane Wood , Wei Hong Yu
- Applicant Address: IE Dun Laoghaire
- Assignee: COVX TECHNOLOGIES IRELAND, LIMITED
- Current Assignee: COVX TECHNOLOGIES IRELAND, LIMITED
- Current Assignee Address: IE Dun Laoghaire
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61P9/00 ; A61P35/00 ; C07K16/00
Abstract:
The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety.The invention further provides specific MAC compounds and compositions of the invention.
Public/Granted literature
- US08741291B2 Multifunctional antibody conjugates Public/Granted day:2014-06-03
Information query
