发明申请
US20120202809A1 NOVEL N-PYRIMIDIN-4-YL-3-AMINO-PYRROLO[3,4-C]PYRAZOLE DERIVATIVES AS PKC KINASE INHIBITORS
有权
新型N-嘧啶-4-基-3-氨基吡咯并[3,4-C]吡唑衍生物作为PKC激酶抑制剂
- 专利标题: NOVEL N-PYRIMIDIN-4-YL-3-AMINO-PYRROLO[3,4-C]PYRAZOLE DERIVATIVES AS PKC KINASE INHIBITORS
- 专利标题(中): 新型N-嘧啶-4-基-3-氨基吡咯并[3,4-C]吡唑衍生物作为PKC激酶抑制剂
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申请号: US13450388申请日: 2012-04-18
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公开(公告)号: US20120202809A1公开(公告)日: 2012-08-09
- 发明人: Hui Li , Seiji Nukui , Stephanie Anne Scales , Min Teng , Chunfeng Yin
- 申请人: Hui Li , Seiji Nukui , Stephanie Anne Scales , Min Teng , Chunfeng Yin
- 专利权人: PFIZER INC.
- 当前专利权人: PFIZER INC.
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; A61K31/506 ; A61K31/4985 ; A61K31/4545 ; A61K31/496 ; A61P3/10 ; A61P35/00 ; A61P9/10 ; A61P29/00 ; A61P25/00 ; A61P9/00 ; A61P25/28 ; A61P17/00 ; A61P31/12 ; A61P1/16 ; A61P13/12 ; A61P27/02 ; C07D487/04
摘要:
The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disase pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.
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