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    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors
    1.
    发明授权
    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors 有权
    N-嘧啶-4-基-3-氨基 - 吡咯并[3,4-c]吡唑衍生物作为PKC激酶抑制剂

    公开(公告)号：US08183255B2

    公开(公告)日：2012-05-22

    申请号：US12523965

    申请日：2008-02-04

    申请人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    发明人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    IPC分类号： A61K31/505

    CPC分类号： C07D519/00 ,  C07D487/04

    摘要： The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: (A) and (B) wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.

    摘要翻译： 本发明涉及式A和B的化合物和药学上可接受的盐：（A）和（B）其中A，B，R1，R2，R3，R4，R5，R6，R7，R8，R9和R10如上所定义 以上。 本发明还涉及包含该化合物和药学上可接受的盐的药物组合物以及治疗糖尿病及其并发症，癌症，局部缺血，炎症，中枢神经系统疾病，心血管疾病，阿尔茨海默病和皮肤病疾病压迫，病毒疾病，炎性反应的方法 疾病或肝脏是靶器官的疾病。

    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors
    3.
    发明授权
    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors 有权
    N-嘧啶-4-基-3-氨基 - 吡咯并[3,4-c]吡唑衍生物作为PKC激酶抑制剂

    公开(公告)号：US08877761B2

    公开(公告)日：2014-11-04

    申请号：US13450388

    申请日：2012-04-18

    申请人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    发明人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    IPC分类号： A01N43/54 ,  C07D403/00 ,  C07D487/04

    CPC分类号： C07D519/00 ,  C07D487/04

    摘要： The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disase pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.

    摘要翻译： 本发明涉及式A和B的化合物和药学上可接受的盐：其中A，B，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10如上所定义。 本发明还涉及包含该化合物和药学上可接受的盐的药物组合物以及治疗糖尿病及其并发症，癌症，局部缺血，炎症，中枢神经系统疾病，心血管疾病，阿尔茨海默氏病和皮肤病学抑制的病毒病，炎性疾病 疾病或肝脏是靶器官的疾病。