发明申请
US20120208840A1 Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors
失效
缩合环吡啶化合物作为鞘氨醇-1-磷酸-2（S1P2）受体的亚型选择性调节剂
- 专利标题： Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors
- 专利标题（中）： 缩合环吡啶化合物作为鞘氨醇-1-磷酸-2（S1P2）受体的亚型选择性调节剂
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申请号： US13498499申请日： 2010-09-28
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公开(公告)号： US20120208840A1公开(公告)日： 2012-08-16
- 发明人: Wenkiu K. Fang , Liming Wang , Evelyn G. Corpuz , Ken Chow , Wha-Bin Im
- 申请人： Wenkiu K. Fang , Liming Wang , Evelyn G. Corpuz , Ken Chow , Wha-Bin Im
- 申请人地址： US CA Irvine
- 专利权人： ALLERGAN, INC.
- 当前专利权人： ALLERGAN, INC.
- 当前专利权人地址： US CA Irvine
- 国际申请： PCT/US2010/050486 WO 20100928
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61K31/4375 ; C07D215/38 ; A61K31/47 ; A61P43/00 ; A61K31/4709 ; A61P27/02 ; A61P9/00 ; A61P37/08 ; A61P29/00 ; C07D471/04 ; C07D401/12
摘要：
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of wherein A, B, C, D, X, Y, Z and R3 are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases; systemic vascular barrier related diseases; allergies and other inflammatory diseases; cardiac diseases or conditions; fibrosis; pain and wounds.