A pressure adjustment device of a chambered doctor blade system of a printing press includes at least one chambered doctor blade, at least one ink chamber having at least one supply line connected to an ink reservoir and having at least one drain line or overflow opening that at least partially forms a return flow path of the medium from the at least one ink chamber to the at least one ink reservoir. At least one pressure release valve is arranged in the one of the drain line or overflow opening. Another pressure release valve is also arranged in the at least one supply line. One of the pressure release valves is configured as a passive pressure release valve. The at least one pressure release valve arranged in the at least one supply line has a line connection to at least one bypass line. That bypass line is arranged to at least partially form a return flow path of the medium from the supply line to the ink reservoir.