发明申请
US20120213785A1 ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES
审中-公开
抗坏血酸激动剂抗体及其在治疗缺血性相关疾病中的应用
- 专利标题： ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES
- 专利标题（中）： 抗坏血酸激动剂抗体及其在治疗缺血性相关疾病中的应用
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申请号： US13453817申请日： 2012-04-23
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公开(公告)号： US20120213785A1公开(公告)日： 2012-08-23
- 发明人: Kang Li , Bin-Bing Stephen Zhou , Wenjuan Wu , Sek Chung Fung , Sanjaya Singh
- 申请人： Kang Li , Bin-Bing Stephen Zhou , Wenjuan Wu , Sek Chung Fung , Sanjaya Singh
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P25/06 ; A61P25/28
摘要：
The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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