发明申请
- 专利标题： CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES
- 专利标题（中）： 卡利辛胺衍生物载体结合物
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申请号： US13372172申请日： 2012-02-13
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公开(公告)号： US20120213804A1公开(公告)日： 2012-08-23
- 发明人: ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
- 申请人： ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
- 申请人地址： US NJ Madison
- 专利权人： WYETH HOLDINGS CORPORATION
- 当前专利权人： WYETH HOLDINGS CORPORATION
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K39/44
- IPC分类号： A61K39/44 ; A61P35/00 ; A61P29/00 ; C07K17/10
摘要：
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
公开/授权文献
- US08835611B2 Calicheamicin derivative-carrier conjugates 公开/授权日：2014-09-16