发明申请
- 专利标题: NOVEL IMMUNOGLOBULIN INSERTIONS, DELETIONS, AND SUBSTITUTIONS
- 专利标题(中): 新的免疫球蛋白插入,删除和取代
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申请号: US13336907申请日: 2011-12-23
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公开(公告)号: US20120225058A1公开(公告)日: 2012-09-06
- 发明人: Gregory A. Lazar , Bassil I. Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
- 申请人: Gregory A. Lazar , Bassil I. Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
- 申请人地址: US CA Monrovia
- 专利权人: Xencor, Inc.
- 当前专利权人: Xencor, Inc.
- 当前专利权人地址: US CA Monrovia
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/24 ; C07K16/28 ; A61P29/00 ; C12N15/13 ; A61P35/00 ; A61P37/06 ; A61P31/00 ; C07K16/00 ; C07K19/00
摘要:
An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
公开/授权文献
- US08399618B2 Immunoglobulin insertions, deletions, and substitutions 公开/授权日:2013-03-19
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