发明申请
US20120225820A1 PEPTIDES ASSOCIATED WITH HLA-DR MHC CLASS II MOLECULE AND INVOLVED IN RHEUMATOID ARTHRITIS
审中-公开
与HLA-DR MHC II类分子相关并涉及RHEUMATOID ARTHRITIS的相关肽
- 专利标题： PEPTIDES ASSOCIATED WITH HLA-DR MHC CLASS II MOLECULE AND INVOLVED IN RHEUMATOID ARTHRITIS
- 专利标题（中）： 与HLA-DR MHC II类分子相关并涉及RHEUMATOID ARTHRITIS的相关肽
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申请号： US13472401申请日： 2012-05-15
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公开(公告)号： US20120225820A1公开(公告)日： 2012-09-06
- 发明人: Jonathan Hill , Ewa Cairns , David Bell
- 申请人： Jonathan Hill , Ewa Cairns , David Bell
- 申请人地址： CA LONDON
- 专利权人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
- 当前专利权人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
- 当前专利权人地址： CA LONDON
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; C07K7/08 ; C07K14/00 ; A61P29/00 ; A61K38/16 ; G01N33/53 ; A01K67/00 ; C07K7/06 ; A61K38/10
摘要：
Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are citrullinated antigenic peptides having an increased affinity for HLA-DR molecules and associated with rheumatoid arthritis. These novel peptides provide the basis for new methods of diagnosis and treatment of rheumatoid arthritis.
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