发明申请
US20120230963A1 Methods and Compositions for Expanding, Identifying, Characterizing and Enhancing Potency of Mammalian-Derived Glial Restricted Progenitor Cells
审中-公开
用于扩增，鉴定，表征和提高哺乳动物衍生的胶质受限祖细胞的效力的方法和组合
- 专利标题： Methods and Compositions for Expanding, Identifying, Characterizing and Enhancing Potency of Mammalian-Derived Glial Restricted Progenitor Cells
- 专利标题（中）： 用于扩增，鉴定，表征和提高哺乳动物衍生的胶质受限祖细胞的效力的方法和组合
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申请号： US13508803申请日： 2010-11-09
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公开(公告)号： US20120230963A1公开(公告)日： 2012-09-13
- 发明人: Robert Sandrock , James T. Campanelli , Deborah A. Eppstein
- 申请人： Robert Sandrock , James T. Campanelli , Deborah A. Eppstein
- 申请人地址： US UT Salt Lake City
- 专利权人： Q Therapeutics, Inc.
- 当前专利权人： Q Therapeutics, Inc.
- 当前专利权人地址： US UT Salt Lake City
- 国际申请： PCT/US10/55956 WO 20101109
- 主分类号： C12N5/0797
- IPC分类号： C12N5/0797 ; C12N5/079 ; A61P25/28 ; C40B30/04 ; A61K35/30 ; A61P25/00 ; C12N13/00 ; C40B40/10
摘要：
Methods for producing a population of human-derived glial restricted progenitor cells (GRPs) with decreased potentially unintended or undesired cellular phenotypes and/or decreased standard deviation in the cells of the population are provided. Also provided are antibody panels and gene expression profiles to characterize GRPs and a method for its use in characterizing GRP cells. In addition methods for use of these GRP cells to generate astrocytes and/or oligodendrocytes, to re-myelinate neurons and to treat glial cell related and other neurodegenerative diseases or disorders or injuries or damage to the nervous system are provided. A method to manufacture neural cells depleted of A2B5 positive cells is also provided.
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