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    Methods and Compositions for Expanding, Identifying, Characterizing and Enhancing Potency of Mammalian-Derived Glial Restricted Progenitor Cells
    1.
    发明申请
    Methods and Compositions for Expanding, Identifying, Characterizing and Enhancing Potency of Mammalian-Derived Glial Restricted Progenitor Cells 审中-公开
    用于扩增，鉴定，表征和提高哺乳动物衍生的胶质受限祖细胞的效力的方法和组合

    公开(公告)号：US20120230963A1

    公开(公告)日：2012-09-13

    申请号：US13508803

    申请日：2010-11-09

    申请人： Robert Sandrock ,  James T. Campanelli ,  Deborah A. Eppstein

    发明人： Robert Sandrock ,  James T. Campanelli ,  Deborah A. Eppstein

    IPC分类号： C12N5/0797 ,  C12N5/079 ,  A61P25/28 ,  C40B30/04 ,  A61K35/30 ,  A61P25/00 ,  C12N13/00 ,  C40B40/10

    CPC分类号： C12N5/0622

    摘要： Methods for producing a population of human-derived glial restricted progenitor cells (GRPs) with decreased potentially unintended or undesired cellular phenotypes and/or decreased standard deviation in the cells of the population are provided. Also provided are antibody panels and gene expression profiles to characterize GRPs and a method for its use in characterizing GRP cells. In addition methods for use of these GRP cells to generate astrocytes and/or oligodendrocytes, to re-myelinate neurons and to treat glial cell related and other neurodegenerative diseases or disorders or injuries or damage to the nervous system are provided. A method to manufacture neural cells depleted of A2B5 positive cells is also provided.

    摘要翻译： 提供了用于产生具有降低的潜在非预期或不需要的细胞表型的人衍生的神经胶质细胞祖细胞（GRP）群体和/或群体细胞中标准偏差降低的方法。 还提供了表征GRP的抗体组和基因表达谱以及用于表征GRP细胞的方法。 另外还提​​供了使用这些GRP细胞产生星形胶质细胞和/或少突胶质细胞，再髓鞘神经元和治疗胶质细胞相关和其它神经变性疾病或障碍或对神经系统的损伤或损伤的方法。 还提供了制备耗尽A2B5阳性细胞的神经细胞的方法。