发明申请
US20120230999A1 BISPECIFIC NANOBODIES AS A THERAPEUTIC FOR ALZHEIMER'S DISEASE
有权
作为阿尔茨海默病的治疗方法的双重性NANOBODIES
- 专利标题： BISPECIFIC NANOBODIES AS A THERAPEUTIC FOR ALZHEIMER'S DISEASE
- 专利标题（中）： 作为阿尔茨海默病的治疗方法的双重性NANOBODIES
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申请号： US13395011申请日： 2010-09-08
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公开(公告)号： US20120230999A1公开(公告)日： 2012-09-13
- 发明人: Michael Sierks , Shanta Boddapati , Srinath Kasturirangan
- 申请人： Michael Sierks , Shanta Boddapati , Srinath Kasturirangan
- 申请人地址： US AZ Scottsdale
- 专利权人： Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of Ariz
- 当前专利权人： Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of Ariz
- 当前专利权人地址： US AZ Scottsdale
- 国际申请： PCT/US10/48080 WO 20100908
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P25/28 ; C12N5/071 ; C12N5/079 ; C07K16/40 ; C12N5/02
摘要：
The present invention provides for the treatment of Alzheimer's disease. More specifically, a recombinant bispecific antibody fragment that simultaneously blocks beta-secretase activity while also promoting alpha-secretase activity, comprising a first portion and a second portion, wherein the first portion blocks beta secretase activity and the second portion promotes alpha-secretase activity.
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