发明申请
- 专利标题： THERMO-RESPONSIVE HYDROGEL COMPOSITIONS
- 专利标题（中）： 热应答水凝胶组合物
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申请号： US13045643申请日： 2011-03-11
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公开(公告)号： US20120231072A1公开(公告)日： 2012-09-13
- 发明人: Jennifer J. KANG-MIELER , Eric BREY , Victor PEREZ-LUNA , Bin JIANG , Pawel DRAPALA , Hans Hitz , Rolf Schaefer
- 申请人： Jennifer J. KANG-MIELER , Eric BREY , Victor PEREZ-LUNA , Bin JIANG , Pawel DRAPALA , Hans Hitz , Rolf Schaefer
- 申请人地址： CH Bubendorf US IL Chicago
- 专利权人： Chemisches Institut Schaefer AG,Illinois Institute of Technology
- 当前专利权人： Chemisches Institut Schaefer AG,Illinois Institute of Technology
- 当前专利权人地址： CH Bubendorf US IL Chicago
- 主分类号： A61K47/30
- IPC分类号： A61K47/30 ; A61K47/32 ; A61K31/573 ; A61P17/02 ; A61P27/02 ; A61K47/18 ; A61K9/48 ; B82Y5/00
摘要：
A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having an amino acid side chain. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.
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