- 专利标题： NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE
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申请号： US13429286申请日： 2012-03-23
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公开(公告)号： US20120237523A1公开(公告)日： 2012-09-20
- 发明人: John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
- 申请人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
- 专利权人： University of Washington,The United States of America, as represented by the Secretary, Dept. of Health & Human Services
- 当前专利权人： University of Washington,The United States of America, as represented by the Secretary, Dept. of Health & Human Services
- 主分类号： A61K39/42
- IPC分类号： A61K39/42 ; C12N15/13 ; A61P31/18 ; G01N33/566 ; G01N33/569 ; C12N1/21 ; C12N5/10 ; C12N1/19 ; C07K16/10 ; C12N15/63
摘要：
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
公开/授权文献
- US08637036B2 Neutralizing antibodies to HIV-1 and their use 公开/授权日：2014-01-28
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