- 专利标题： MUTANT INTERLEUKIN-2 POLYPEPTIDES
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申请号： US13367843申请日： 2012-02-07
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公开(公告)号： US20120244112A1公开(公告)日： 2012-09-27
- 发明人: Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
- 申请人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
- 优先权： EP11153964.9 20110210; EP11164237.7 20110429
- 主分类号： C07K14/55
- IPC分类号： C07K14/55 ; A61P35/00 ; C12P21/00 ; A61K38/20 ; C07H21/04 ; C12N15/63
摘要：
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
公开/授权文献
- US09266938B2 Mutant interleukin-2 polypeptides 公开/授权日：2016-02-23