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公开(公告)号：US20120244112A1
公开(公告)日：2012-09-27
申请号：US13367843
申请日：2012-02-07
申请人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
CPC分类号： C07K16/40 , A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6871 , A61K47/6891 , A61K2039/505 , C07K14/55 , C07K16/30 , C07K2319/00
摘要： The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
摘要翻译： 本发明一般涉及对IL-2受体的α亚基表现出降低的亲和力的突变白细胞介素-2多肽，用作免疫治疗剂。 此外，本发明涉及包含所述突变型IL-2多肽，编码突变型IL-2多肽或免疫缀合物的多核苷酸分子以及包含该多核苷酸分子的载体和宿主细胞的免疫缀合物。 本发明还涉及用于产生突变型IL-2多肽或免疫缀合物的方法，包含其的药物组合物及其用途。
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公开(公告)号：US09266938B2
公开(公告)日：2016-02-23
申请号：US13367843
申请日：2012-02-07
申请人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valerla G. Nicolini , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valerla G. Nicolini , Pablo Umana
CPC分类号： C07K16/40 , A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6871 , A61K47/6891 , A61K2039/505 , C07K14/55 , C07K16/30 , C07K2319/00
摘要： The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
摘要翻译： 本发明一般涉及对IL-2受体的α亚基表现出降低的亲和力的突变白细胞介素-2多肽，用作免疫治疗剂。 此外，本发明涉及包含所述突变型IL-2多肽，编码突变型IL-2多肽或免疫缀合物的多核苷酸分子以及包含该多核苷酸分子的载体和宿主细胞的免疫缀合物。 本发明还涉及用于产生突变型IL-2多肽或免疫缀合物的方法，包含其的药物组合物及其用途。
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公开(公告)号：US20120039807A1
公开(公告)日：2012-02-16
申请号：US13207705
申请日：2011-08-11
申请人： Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
发明人： Anne Freimoser-Grundschober , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
IPC分类号： A61K39/395 , C12N15/13 , C12N5/10 , A61P35/00 , C12N1/15 , C12N1/19 , C12P21/00 , A61K49/00 , C07K16/18 , C12N1/21
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6851 , A61K49/0058 , A61K51/1018 , C07K16/30 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The invention provides antibodies against the A2 domain of tenascin-C and methods of using the same.
摘要翻译： 本发明提供针对腱生蛋白C的A2结构域的抗体及其使用方法。
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公开(公告)号：US09447159B2
公开(公告)日：2016-09-20
申请号：US13457039
申请日：2012-04-26
申请人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K16/46 , C07K14/54 , C07K14/55 , A61K47/48 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/40 , A61K39/44 , C12N15/13 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K16/40 , A61K38/2013 , A61K39/395 , A61K47/6813 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/52 , C07K14/5434 , C07K14/55 , C07K16/18 , C07K16/283 , C07K16/2866 , C07K16/30 , C07K16/3007 , C07K16/46 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/74
摘要： The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
摘要翻译： 本发明一般涉及用于选择性递送影响细胞活性的效应部分的抗原特异性免疫偶联物。 更具体地，本发明提供了包含第一抗原结合部分，Fc结构域和单个效应子部分的新型免疫偶联物。 此外，本发明涉及编码这种免疫缀合物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的免疫缀合物的制备方法，以及使用这些免疫缀合物治疗疾病的方法。
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公开(公告)号：US20120276125A1
公开(公告)日：2012-11-01
申请号：US13457039
申请日：2012-04-26
申请人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K16/46 , C12N15/13 , A61P37/04 , C12N5/10 , C12P21/00 , A61K39/44 , C07K14/55 , C12N15/63
CPC分类号： C07K16/40 , A61K38/2013 , A61K39/395 , A61K47/6813 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/52 , C07K14/5434 , C07K14/55 , C07K16/18 , C07K16/283 , C07K16/2866 , C07K16/30 , C07K16/3007 , C07K16/46 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/74
摘要： The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
摘要翻译： 本发明一般涉及用于选择性递送影响细胞活性的效应部分的抗原特异性免疫偶联物。 更具体地，本发明提供了包含第一抗原结合部分，Fc结构域和单个效应子部分的新型免疫偶联物。 此外，本发明涉及编码这种免疫缀合物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的免疫缀合物的制备方法，以及使用这些免疫缀合物治疗疾病的方法。
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公开(公告)号：US20130078249A1
公开(公告)日：2013-03-28
申请号：US13590886
申请日：2012-08-21
申请人： Oliver Ast , Peter Bruenker , Tanja Fauti , Anne Freimoser-Grundschober , Christiane Jaeger , Christian Klein , Ekkehard Moessner , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Tanja Fauti , Anne Freimoser-Grundschober , Christiane Jaeger , Christian Klein , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/2809 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US20120251529A1
公开(公告)日：2012-10-04
申请号：US13408171
申请日：2012-02-29
申请人： Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
发明人： Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
CPC分类号： C07K16/42 , A61K39/39566 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K16/3007 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention provides antigen binding molecules (ABMs) which bind membrane-bound CEA, including ABMs with improved therapeutic properties, and methods of using the same.
摘要翻译： 本发明提供了结合膜结合CEA的抗原结合分子（ABM），其包括具有改善的治疗性质的ABM及其使用方法。
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公开(公告)号：US08642742B2
公开(公告)日：2014-02-04
申请号：US13408171
申请日：2012-02-29
申请人： Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
发明人： Thomas U. Hofer , Ralf Hosse , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/42 , A61K39/39566 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K16/3007 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention provides antigen binding molecules (ABMs) which bind membrane-bound CEA, including ABMs with improved therapeutic properties, and methods of using the same.
摘要翻译： 本发明提供了结合膜结合CEA的抗原结合分子（ABM），其包括具有改善的治疗性质的ABM及其使用方法。
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公开(公告)号：US20120258073A1
公开(公告)日：2012-10-11
申请号：US13367881
申请日：2012-02-07
IPC分类号： A61K39/395 , A61P35/00 , A61P37/04
CPC分类号： C07K16/32 , A61K38/00 , A61K38/2013 , A61K45/06 , A61K47/6813 , C07K14/52 , C07K19/00 , C07K2319/33 , A61K2300/00
摘要： The present invention provides combinations of (a) an immunoconjugate comprising at least one antigen-binding moiety and an effector moiety, and (b) an antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.
摘要翻译： 本发明提供了（a）包含至少一个抗原结合部分和效应部分的免疫偶联物的组合，和（b）工程改造成具有增强的效应子功能的抗体，用于治疗有需要的个体中的疾病。 还提供了包含组合的药物组合物和使用它们的方法。
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公开(公告)号：US09481730B2
公开(公告)日：2016-11-01
申请号：US13498390
申请日：2010-09-27
申请人： Peter Bruenker , Claudia Ferrara Koller , Sandra Grau , Sylvia Herter , Christoph Lampert , Ekkehard Moessner , Pablo Umana , Inja Waldhauer
发明人： Peter Bruenker , Claudia Ferrara Koller , Sandra Grau , Sylvia Herter , Christoph Lampert , Ekkehard Moessner , Pablo Umana , Inja Waldhauer
CPC分类号： C07K16/2878 , C07K16/18 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及包含对死亡受体特异性的第一抗原结合位点和第二抗原特异性的第二抗原结合位点的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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