发明申请
US20120245176A1 NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS
审中-公开
具有替代性荧光素酶的新型哌嗪类似物作为广谱流感病毒
- 专利标题： NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS
- 专利标题（中）： 具有替代性荧光素酶的新型哌嗪类似物作为广谱流感病毒
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申请号： US13242676申请日： 2011-09-23
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公开(公告)号： US20120245176A1公开(公告)日： 2012-09-27
- 发明人: Christopher W. Cianci , Samuel Gerritz , Sean Kim , David R. Langley , Guo Li , Bradley C. Pearce , Annapurna Pendri , Shuhao Shi , Weixu Zhai , Shirong Zhu
- 申请人： Christopher W. Cianci , Samuel Gerritz , Sean Kim , David R. Langley , Guo Li , Bradley C. Pearce , Annapurna Pendri , Shuhao Shi , Weixu Zhai , Shirong Zhu
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D413/14 ; A61K31/506 ; A61P31/16 ; C07D403/06 ; C07D401/14 ; C07D417/06 ; A61P31/12 ; C07D413/06 ; A61K31/498
摘要：
A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with —N, —O, or —S adjacent to the —Ar substituent or adjacent to the point of attachment for the —Ar substituent; Ar is aryl or heteroaryl; R is —CH3, —CH2F, —CHF2 or —CH═CH2; V is —H, —CH3 or ═O; W is —NO2, —Cl, —Br, —CH2OH, or —CN; X is —Cl, —Br, —F, —CH3, —OCH3, or —CN; Y is —CH or —N; and Z is —CH or —N. This compound is useful in compositions for the prevention and treatment of influenza virus.