发明申请
US20120245185A1 ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
有权
ARYL和HETEROARYL SULFONES作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法
- 专利标题： ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
- 专利标题（中）： ARYL和HETEROARYL SULFONES作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法
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申请号： US13508535申请日： 2010-11-08
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公开(公告)号： US20120245185A1公开(公告)日： 2012-09-27
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
- 申请人地址： US TN Nashville
- 专利权人： VANDERBILT UNIVERSITY
- 当前专利权人： VANDERBILT UNIVERSITY
- 当前专利权人地址： US TN Nashville
- 国际申请： PCT/US10/55861 WO 20101108
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D417/04 ; A61K31/427 ; C07D213/81 ; C12N5/02 ; C07D307/68 ; A61K31/341 ; C07D239/28 ; A61K31/505 ; C07D401/04 ; A61K31/4402
摘要：
In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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