发明申请
US20120245200A1 CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION
审中-公开
喹啉化合物的晶体形式及其生产工艺
- 专利标题： CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION
- 专利标题（中）： 喹啉化合物的晶体形式及其生产工艺
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申请号： US13487289申请日： 2012-06-04
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公开(公告)号： US20120245200A1公开(公告)日： 2012-09-27
- 发明人: Yoshio OHARA , Yasutaka Takada , Hiroo Matsumoto , Akihiro Yoshida
- 申请人： Yoshio OHARA , Yasutaka Takada , Hiroo Matsumoto , Akihiro Yoshida
- 申请人地址： JP Chiyoda-ku
- 专利权人： NISSAN CHEMICAL INDUSTRIES, LTD.
- 当前专利权人： NISSAN CHEMICAL INDUSTRIES, LTD.
- 当前专利权人地址： JP Chiyoda-ku
- 优先权： JP2003-431788 20031226
- 主分类号： C07D215/14
- IPC分类号： C07D215/14 ; A61P3/06 ; A61K31/47
摘要：
A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1): The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form A, thereby to obtain a drug substance excellent in stability.
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