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    Process for producing optically active dihydropyridinephosphonic ester
    4.
    发明申请
    Process for producing optically active dihydropyridinephosphonic ester 审中-公开
    光学活性二氢吡啶膦酸酯的制备方法

    公开(公告)号：US20060276437A1

    公开(公告)日：2006-12-07

    申请号：US10573972

    申请日：2004-08-12

    申请人： Yasutaka Takada ,  Hiroo Matsumoto

    发明人： Yasutaka Takada ,  Hiroo Matsumoto

    IPC分类号： A61K31/675 ,  C07F9/58

    CPC分类号： C07F9/657181 ,  C07B2200/07

    摘要： There is provided a process for efficiently producing an optically active substance of efonidipine that is useful as an antihypertensive agent or a therapeutic agent for angina pectoris. A process for producing an optically active substance of compound of formula (1) characterized by comprising: dissolving a racemate of the compound of formula (1) in a solvent to prepare a supersaturated solution; and adding crystal of either one optically active substance of the compound of formula (1) as a seed crystal in the supersaturated solution to allow crystal of the one optically active substance added as the seed crystal to separate out; or dissolving a mixture of the compound of formula (1) in which either one optically active substance thereof is present in excess in a solvent to prepare a supersaturated solution; and adding crystal of the one optically active substance present in excess as a seed crystal in the supersaturated solution to allow crystal of the one optically active substance present in excess to separate out.

    摘要翻译： 提供了有效地制备作为抗高血压药或心绞痛治疗剂有效的依非西汀的光学活性物质的方法。 一种制备式（1）化合物的光学活性物质的方法，其特征在于包括：将式（1）化合物的外消旋物质溶解在溶剂中以制备过饱和溶液; 并在过饱和溶液中加入式（1）化合物的一种光学活性物质作为晶种的结晶，使得作为晶种加入的一种光学活性物质的晶体分离出来; 或将其中一种光学活性物质过量存在于溶剂中的式（1）化合物的混合物以制备过饱和溶液; 并将过量存在的一种光学活性物质的晶体作为晶种添加到过饱和溶液中，以使过量存在的一种光学活性物质的结晶分离出来。

    Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative
    5.
    发明申请
    Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative 失效
    高纯度3,5-二羟基-6-庚烯酸衍生物的制备方法

    公开(公告)号：US20060229451A1

    公开(公告)日：2006-10-12

    申请号：US10568347

    申请日：2004-09-22

    申请人： Yuji Yoshimura ,  Masami Yasukawa ,  Syuji Morikiyo ,  Yasutaka Takada ,  Hiroo Matsumoto

    发明人： Yuji Yoshimura ,  Masami Yasukawa ,  Syuji Morikiyo ,  Yasutaka Takada ,  Hiroo Matsumoto

    IPC分类号： C07D215/14

    CPC分类号： C07D215/14

    摘要： A process for producing a high purity 3,5-dihydroxy6-heptenoic acid derivative by controlling the content of impurities such as denatured substances, is provided. When a 3,5-dihydroxy-6-heptenoic acid derivative is produced by a process which comprises a step of contacting the 3,5-dihydroxy-6-heptenoic acid derivative of the formula (1) wherein R is a C1-4 alkyl group, with a C1-4 lower alcohol-containing solvent, an alcohol containing solvent having its content of an oxidizing substance lowered, is used to at most 0.05 molar equivalent to a 3,5-dihydroxy-6-heptenoic acid derivative, to suppress impurities contained in the 3,5-dihydroxy-6heptenoic acid derivative.

    摘要翻译： 提供了通过控制诸如变性物质等杂质的含量来生产高纯度3,5-二羟基-6-庚烯酸衍生物的方法。 当3,5-二羟基-6-庚烯酸衍生物通过包括使式（1）的3,5-二羟基-6-庚烯酸衍生物与其中R为C 1 -C 6烷基的式 1-4 C 1-4烷基与含C 1-4低级醇的溶剂，其含有氧化物质含量的醇的溶剂的含量最低为0.05摩尔当量 与3,5-二羟基-6-庚烯酸衍生物反应，以抑制3,5-二羟基-6-庚烯酸衍生物中所含的杂质。

    Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative
    8.
    发明授权
    Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative 失效
    高纯度3,5-二羟基-6-庚烯酸衍生物的制备方法

    公开(公告)号：US07692018B2

    公开(公告)日：2010-04-06

    申请号：US10568347

    申请日：2004-09-22

    申请人： Yuji Yoshimura ,  Masami Yasukawa ,  Syuji Morikiyo ,  Yasutaka Takada ,  Hiroo Matsumoto

    发明人： Yuji Yoshimura ,  Masami Yasukawa ,  Syuji Morikiyo ,  Yasutaka Takada ,  Hiroo Matsumoto

    IPC分类号： C07D215/12

    CPC分类号： C07D215/14

    摘要： A process for producing a high purity 3,5-dihydroxy6-heptenoic acid derivative by controlling the content of impurities such as denatured substances, is provided. When a 3,5-dihydroxy-6-heptenoic acid derivative is produced by a process which comprises a step of contacting the 3,5-dihydroxy-6-heptenoic acid derivative of the formula (1) wherein R is a C1-4 alkyl group, with a C1-4 lower alcohol-containing solvent, an alcohol containing solvent having its content of an oxidizing substance lowered, is used to at most 0.05 molar equivalent to a 3,5-dihydroxy-6-heptenoic acid derivative, to suppress impurities contained in the 3,5-dihydroxy-6heptenoic acid derivative.

    摘要翻译： 提供了通过控制诸如变性物质等杂质的含量来生产高纯度3,5-二羟基-6-庚烯酸衍生物的方法。 当3,5-二羟基-6-庚烯酸衍生物通过包括使式（1）的3,5-二羟基-6-庚烯酸衍生物与其中R为C 1-4烷基的式 使用含有低级醇的C 1-4的溶剂，将含有氧化物质含量的醇的溶剂降低至与3,5-二羟基-6-庚烯酸衍生物最多0.05摩尔当量以抑制 杂质含在3,5-二羟基-6-庚烯酸衍生物中。

    Process for producing quinolinecarbaldehyde
    9.
    发明授权
    Process for producing quinolinecarbaldehyde 有权
    制备喹啉甲醛的方法

    公开(公告)号：US06437135B1

    公开(公告)日：2002-08-20

    申请号：US09868904

    申请日：2001-07-09

    申请人： Hiroo Matsumoto ,  Takanori Shimizu ,  Yasutaka Takada

    发明人： Hiroo Matsumoto ,  Takanori Shimizu ,  Yasutaka Takada

    IPC分类号： C07D21514

    CPC分类号： C07D215/14

    摘要： A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde, which entails oxidizing 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline with a salt of a hypohalogenous acid in the presence of a quaternary ammonium salt.

    摘要翻译： 一种2-环丙基-4-（4-氟苯基） - 喹啉-3-甲醛的制备方法，该方法需要在存在下用次卤酸的盐氧化2-环丙基-4-（4-氟苯基）-3-羟甲基喹啉 的季铵盐。

    Process for preparing optically active mevalonolactone compounds
    10.
    发明授权
    Process for preparing optically active mevalonolactone compounds 失效
    光学活性甲羟戊酸内酯化合物的制备方法

    公开(公告)号：US5939552A

    公开(公告)日：1999-08-17

    申请号：US700396

    申请日：1996-08-22

    申请人： Hirokazu Ikeda ,  Tatsushi Murakami ,  Hiroo Matsumoto ,  Yoshio Ohara ,  Hiroyasu Kanda

    发明人： Hirokazu Ikeda ,  Tatsushi Murakami ,  Hiroo Matsumoto ,  Yoshio Ohara ,  Hiroyasu Kanda

    IPC分类号： B01D15/18 ,  B01D15/38 ,  C07C59/01 ,  C07D215/14 ,  C07D405/06 ,  C07D215/00

    CPC分类号： B01D15/3833 ,  B01D15/185 ,  B01J20/262 ,  B01J20/265 ,  B01J20/285 ,  B01J20/3272 ,  B01J20/328 ,  C07C59/01 ,  C07D215/14 ,  C07D405/06

    摘要： The process for preparing mevalonolactone compounds is carried out by means of batch system chromatography or a simulated moving bed chromatographic process using columns filled with an optical resolution filler comprising a polysaccharide derivative. The simulated moving bed chromatographic process comprises forming a circulation flow circuit comprising a plurality of columns endlessly connected in series; enforcing a fluid to flow through the circuit in one direction; providing the column series alternately with an inlet port through which the fluid is introduced into the column in the flow direction and with an outlet port, through which the fluid is taken out; intermittently shifting activation of the inlet port and the outlet port in the direction of the fluid flow; introducing a solution containing a racemic mevalonolactone compound and an eluent through an inlet port into the circuit; and simultaneously taking out a solution rich in the weakly adsorbable substance and a solution rich in the strongly adsorbable and desorbed substance through the outlet port.

    摘要翻译： PCT No.PCT / JP95 / 00251 Sec。 371日期：1996年8月22日 102（e）日期1996年8月22日PCT提交1995年2月22日PCT公布。 公开号WO95 / 23125 日期1995年8月31日制备甲羟戊酸内酯化合物的方法通过间歇系统色谱法或使用填充有包含多糖衍生物的光学拆分填料的柱的模拟移动床层析法进行。 模拟移动床层析方法包括形成循环流动回路，其包括多个串联连续的列; 强制流体在一个方向流过电路; 提供柱系列与入口端口交替流动，流体通过该入口沿流动方向引入塔中，并具有出口，通过该出口端口取出流体; 在流体流动的方向上间歇地移动入口和出口的活化; 将含有外消旋甲羟戊酸内酯化合物和洗脱液的溶液通过入口引入电路; 并通过出口同时取出富含弱吸附物质的溶液和富含强吸附和解吸物质的溶液。