发明申请
- 专利标题： POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN THE MEDICINAL PREPARATIONS
- 专利标题（中）： 益生菌多形态，其生产过程及其在药物制剂中的应用
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申请号： US13488345申请日： 2012-06-04
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公开(公告)号： US20120245355A1公开(公告)日： 2012-09-27
- 发明人: Giuseppe Claudio VISCOMI , Manuela CAMPANA , Donatella CONFORTINI , Maria Miriam BARBANTI , Dario BRAGA
- 申请人： Giuseppe Claudio VISCOMI , Manuela CAMPANA , Donatella CONFORTINI , Maria Miriam BARBANTI , Dario BRAGA
- 申请人地址： IT Bologna
- 专利权人： ALFA WASSERMANN, S.P.A.
- 当前专利权人： ALFA WASSERMANN, S.P.A.
- 当前专利权人地址： IT Bologna
- 优先权： EP05004695.2 20050303
- 主分类号： C07D491/22
- IPC分类号： C07D491/22
摘要：
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
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