公开(公告)号：US20120245355A1

公开(公告)日：2012-09-27

申请号：US13488345

申请日：2012-06-04

申请人： Giuseppe Claudio VISCOMI ,  Manuela CAMPANA ,  Donatella CONFORTINI ,  Maria Miriam BARBANTI ,  Dario BRAGA

发明人： Giuseppe Claudio VISCOMI ,  Manuela CAMPANA ,  Donatella CONFORTINI ,  Maria Miriam BARBANTI ,  Dario BRAGA

IPC分类号： C07D491/22

CPC分类号： C07D491/22 ,  A61K9/0053 ,  A61K31/437 ,  C07B2200/13 ,  C07D498/22

摘要： Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.

摘要翻译： 名为利福昔明δ和利福昔明的利福昔明（INN）抗生素的结晶多形态 可用于生产含有利福昔明用于口服和局部使用的药物制剂，并且通过将原来的利福昔明热溶解在乙醇中进行的结晶方法获得，并且通过在确定的温度下加入水使产物结晶 并且在一段确定的时间段内，随后在受控条件下进行干燥，直到达到最终产品中的沉降含水量为止，是本发明的目的。