Invention Application
- Patent Title: METHODS FOR COVALENT LINKING OF OPTICAL REPORTERS
- Patent Title (中): 光学报告器共同连接方法
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Application No.: US13357521Application Date: 2012-01-24
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Publication No.: US20120252025A1Publication Date: 2012-10-04
- Inventor: Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
- Applicant: Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
- Assignee: APDN, Inc.
- Current Assignee: APDN, Inc.
- Main IPC: C07H1/00
- IPC: C07H1/00 ; C07H21/04 ; G01N21/63 ; G01N27/72 ; C12Q1/68 ; G01N21/64 ; B82Y15/00

Abstract:
A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particle generated by the methods of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.
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