发明申请
US20120258873A1 REDUCTION OF 2,3-DIHYDROXY-2-METHYL BUTYRATE (DHMB) IN BUTANOL PRODUCTION
审中-公开
在丁醇生产中减少2,3-二羟基-2-甲基丁酸（DHMB）
- 专利标题： REDUCTION OF 2,3-DIHYDROXY-2-METHYL BUTYRATE (DHMB) IN BUTANOL PRODUCTION
- 专利标题（中）： 在丁醇生产中减少2,3-二羟基-2-甲基丁酸（DHMB）
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申请号： US13153866申请日： 2011-06-06
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公开(公告)号： US20120258873A1公开(公告)日： 2012-10-11
- 发明人: KATHARINE J. GIBSON , Arthur Leo Kruckeberg , Lori Ann Maggio-Hall , Mark J. Nelson , Ranjan Patnaik
- 申请人： KATHARINE J. GIBSON , Arthur Leo Kruckeberg , Lori Ann Maggio-Hall , Mark J. Nelson , Ranjan Patnaik
- 申请人地址： US DE Wilmington
- 专利权人： Butamax(TM) Advanced Biofuels LLC
- 当前专利权人： Butamax(TM) Advanced Biofuels LLC
- 当前专利权人地址： US DE Wilmington
- 主分类号： C40B30/00
- IPC分类号： C40B30/00 ; C12P7/16 ; C07C31/12 ; C12N1/19
摘要：
The invention relates generally to the field of industrial microbiology and butanol production. More specifically, the invention relates methods of reducing 2,3-dihydroxy-2-methyl butyrate (DHMB) in butanol production. DHMB can be reduced by inhibiting the reduction of acetolactate to DHMB, for example, by knocking out enzymes that catalyze the reduction or by removing DHMB during or after fermentation. Yeast strains, compositions, and methods for reducing DHMB and increasing butanol yield are provided.
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