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公开(公告)号：US20110312053A1
公开(公告)日：2011-12-22
申请号：US13162631
申请日：2011-06-17
Applicant: KEITH H. BURLEW , Robert Dicosimo , Michael Charles Grady , Ranjan Patnaik
Inventor： KEITH H. BURLEW , Robert Dicosimo , Michael Charles Grady , Ranjan Patnaik
CPC classification number: C12P7/16 , A23K10/38 , B01D3/002 , B01D11/0492 , B01D21/26 , B01D21/262 , C07C29/86 , C11B1/025 , C11B13/00 , C12F3/10 , C12M1/00 , C12M21/12 , C12M45/04 , C12M45/09 , C12N1/14 , C12N15/00 , C12P7/18 , C12P7/6418 , Y02E50/10 , Y02E50/16 , Y02E50/17 , Y02W30/74
Abstract: Fatty acids derived from biomass at a step in a fermentation process can be added to a fermentation medium comprising a recombinant microorganism that produces a product alcohol. At least one of growth rate and fermentable carbon consumption of the microorganism is greater in the presence of the fatty acids than the growth rate and the fermentable carbon consumption of the microorganism in the absence of the fatty acids. The addition of the fatty acids can increase glucose consumption, and can improve microorganism biomass production (cell growth/density) and growth rate, thereby reducing production time and increasing productivity of the fermentation process.
Abstract translation: 在发酵过程中的步骤中衍生自生物质的脂肪酸可以加入到包含产生产物醇的重组微生物的发酵培养基中。 在存在脂肪酸的情况下，微生物的生长速率和可发酵碳消耗量中的至少一种比在不存在脂肪酸时微生物的生长速率和可发酵碳消耗量更大。 脂肪酸的添加可以增加葡萄糖消耗，并且可以改善微生物生物量的生产（细胞生长/密度）和生长速率，从而减少生产时间并提高发酵过程的生产率。
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2.发明申请METHOD FOR PRODUCING BUTANOL USING EXTRACTIVE FERMENTATION WITH ELECTROLYTE ADDITION 有权使用电解质添加剂提取发酵生产丁醇的方法公开(公告)号：US20110159558A1
公开(公告)日：2011-06-30
申请号：US12952480
申请日：2010-11-23
Applicant: MICHAEL CHARLES GRADY , RANJAN PATNAIK
Inventor： MICHAEL CHARLES GRADY , RANJAN PATNAIK
Abstract: A method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one electrolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the presence of the salt concentration of the basal fermentation medium, is provided. The electrolyte may comprise a salt which dissociates in the fermentation medium, or in the aqueous phase of a biphasic fermentation medium, to form free ions. Also provided is a method and composition for recovering butanol from a fermentation medium.
Abstract translation: 一种通过微生物发酵生产丁醇的方法，其中在发酵过程中将丁醇产物在至少一种电解质存在下，以至少足以提高丁醇分配系数的浓度至少提高至不溶于水的有机萃取剂中去除 在提供基础发酵培养基的盐浓度的情况下。 电解质可以包含在发酵培养基中或在双相发酵培养基的水相中解离形成游离离子的盐。 还提供了用于从发酵培养基中回收丁醇的方法和组合物。
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3.发明申请METHOD FOR PRODUCING BUTANOL USING EXTRACTIVE FERMENTATION WITH OSMOLYTE ADDITION 审中-公开使用提取发酵的苹果酸添加剂生产丁醇的方法公开(公告)号：US20110136193A1
公开(公告)日：2011-06-09
申请号：US12952549
申请日：2010-11-23
Applicant: MICHAEL CHARLES GRADY , RANJAN PATNAIK
Inventor： MICHAEL CHARLES GRADY , RANJAN PATNAIK
Abstract: A method is provided for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one osmolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the presence of the osmolyte concentration of the basal fermentation medium and of an optional fermentable carbon source. The osmolyte may comprise a monosaccharide, a disaccharide, glycerol, sugarcane juice, molasses, polyethylene glycol, dextran, high fructose corn syrup, corn mash, starch, cellulose, and combinations thereof. Also provided is a method and composition for recovering butanol from a fermentation medium.
Abstract translation: 提供了一种通过微生物发酵生产丁醇的方法，其中在发酵过程中将丁醇产物在至少一种渗透剂存在下萃取至与水不混溶的有机萃取剂中，其浓度至少足以提高丁醇分配系数 相对于在基础发酵培养基和任选的可发酵碳源的渗透液浓度存在下的浓度。 渗透剂可以包含单糖，二糖，甘油，甘蔗汁，糖蜜，聚乙二醇，葡聚糖，高果糖玉米糖浆，玉米糊，淀粉，纤维素及其组合。 还提供了用于从发酵培养基中回收丁醇的方法和组合物。
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公开(公告)号：US20100221802A1
公开(公告)日：2010-09-02
申请号：US12759283
申请日：2010-04-13
Applicant: MICHAEL CHARLES GRADY , MEHMEDALIJA JAHIC , RANJAN PATNAIK
Inventor： MICHAEL CHARLES GRADY , MEHMEDALIJA JAHIC , RANJAN PATNAIK
Abstract: A method of making butanol from at least one fermentable carbon source that overcomes the issues of toxicity resulting in an increase in the effective titer, the effective rate, and the effective yield of butanol production by fermentation utilizing a recombinant microbial host wherein the butanol is extracted into specific organic extractants during fermentation
Abstract translation: 一种从至少一种可发酵碳源制造丁醇的方法，其克服了毒性问题，导致通过使用重组微生物宿主发酵的丁醇生产的有效滴度，有效速率和有效产率提高，其中提取丁醇 在发酵过程中变成特定的有机萃取剂
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5.发明申请公开(公告)号：US20100144000A1
公开(公告)日：2010-06-10
申请号：US12328392
申请日：2008-12-04
Applicant: Jeanine M. Erdner-Tindall , Keith W. Hutchenson , Mark Brandon Shiflett , Ranjan Patnaik
IPC: C12P7/06
CPC classification number: C12P7/06 , C07C29/86 , Y02E50/17 , Y02P20/542 , C07C31/08
Abstract: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
Abstract translation: 本发明涉及使用液 - 液萃取从发酵液中回收醇的方法，其中使用至少一种离子液体作为萃取溶剂。
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Patent Agency Ranking
公开(公告)号：US20100143999A1
公开(公告)日：2010-06-10
申请号：US12328300
申请日：2008-12-04
Applicant: Jeanine M. Erdner-Tindall , Keith W. Hutchenson , Mark Brandon Shiflett , Ranjan Patnaik
IPC: C12P7/06
CPC classification number: C12P7/06 , Y02E50/17 , Y02P20/542
Abstract: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
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公开(公告)号：US20100143995A1
公开(公告)日：2010-06-10
申请号：US12328336
申请日：2008-12-04
Applicant: Jeanine M. Erdner-Tindall , Keith W. Hutchenson , Mark Brandon Shiflett , Ranjan Patnaik
IPC: C12P7/16
CPC classification number: C12P7/16 , B01D11/0446 , Y02E50/10 , Y02E50/17 , Y02P20/542
Abstract: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
Abstract translation: 本发明涉及使用液 - 液萃取从发酵液中回收醇的方法，其中使用至少一种离子液体作为萃取溶剂。
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8.发明申请公开(公告)号：US20100143994A1
公开(公告)日：2010-06-10
申请号：US12328308
申请日：2008-12-04
Applicant: Jeanine M. Erdner-Tindall , Keith W. Hutchenson , Mark Brandon Shiflett , Ranjan Patnaik
IPC: C12P7/16
CPC classification number: C12P7/06 , B01D11/0446 , C07C29/86 , C10G2300/1011 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y02P20/542 , Y02P30/20 , C07C31/12
Abstract: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.
Abstract translation: 本发明涉及使用液 - 液萃取从发酵液中回收醇的方法，其中使用至少一种离子液体作为萃取溶剂。
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公开(公告)号：US07700328B2
公开(公告)日：2010-04-20
申请号：US11448331
申请日：2006-06-07
Applicant: Anthony A. Gatenby , Ranjan Patnaik , Fateme Sima Sariaslani , Wonchul Suh , Tina K. Van Dyk
Inventor： Anthony A. Gatenby , Ranjan Patnaik , Fateme Sima Sariaslani , Wonchul Suh , Tina K. Van Dyk
CPC classification number: C12P13/225
Abstract: An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine production.
Abstract translation: 使用一步法将肠道细菌菌株设计为过度产生L-酪氨酸。 细菌基因组的pheA-tyrA染色体区被工程染色体片段替代，导致pheA编码区的失活和tyrA编码区的强表达，导致高水平的L-酪氨酸产生。
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公开(公告)号：US20090305370A1
公开(公告)日：2009-12-10
申请号：US12478389
申请日：2009-06-04
Applicant: Michael Charles Grady , Mehmedalija Jahic , Ranjan Patnaik
Inventor： Michael Charles Grady , Mehmedalija Jahic , Ranjan Patnaik
Abstract: A method of making butanol from at least one fermentable carbon source that overcomes the issues of toxicity resulting in an increase in the effective titer, the effective rate, and the effective yield of butanol production by fermentation utilizing a recombinant microbial host wherein the butanol is extracted into specific organic extractants during fermentation
Abstract translation: 一种从至少一种可发酵碳源制造丁醇的方法，其克服了毒性问题，导致通过使用重组微生物宿主发酵的丁醇生产的有效滴度，有效速率和有效产率提高，其中提取丁醇 在发酵过程中变成特定的有机萃取剂
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