发明申请
- 专利标题： COACERVATION PROCESS
- 专利标题（中）： 采购流程
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申请号： US13335667申请日： 2011-12-22
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公开(公告)号： US20120258914A1公开(公告)日： 2012-10-11
- 发明人: Rajesh Kumar , Gregory Troiano , J. Michael Ramstack , Paul Herbert , Michael Figa
- 申请人： Rajesh Kumar , Gregory Troiano , J. Michael Ramstack , Paul Herbert , Michael Figa
- 申请人地址： US MA Waltham
- 专利权人： Alkermes, Inc.
- 当前专利权人： Alkermes, Inc.
- 当前专利权人地址： US MA Waltham
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61P3/04 ; A61P3/10
摘要：
Methods of forming compositions for the sustained release of water soluble active agents, including biologically active polypeptides and products produced by the process are described. Improved product characteristics and ease of scale-up can be achieved using a novel coacervation process wherein at least one coacervation agent is added to the mixture comprising the active agent and the polymer in at least two distinct stages.
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