Systems and methods for designing, using, and/or implementing beacon-enabled communications for variable payload transfers are described. In various embodiments, these systems and methods may be applicable to power line communications (PLC). For example, a method may include implementing a superframe having a plurality of beacon slots, a plurality of intermediate slots following the beacon slots, and a poll-based Contention Free Period (CFP) slot following the intermediate slots. Each of the beacon slots and each of the intermediate slots may correspond to a respective one of a plurality of frequency subbands, and the poll-based CFP slot may correspond to a combination of the plurality of frequency subbands. The method may also include receiving a poll request over a first of the plurality of frequency subbands during the poll-based CFP slot, and then transmitting a data packet over a second of the plurality of frequency subbands during the poll-based CFP slot.