发明申请
US20120264687A1 MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED
审中-公开
添加了可溶性长链分子的改良的红细胞膜蛋白
- 专利标题： MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED
- 专利标题（中）： 添加了可溶性长链分子的改良的红细胞膜蛋白
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申请号： US13395534申请日： 2010-09-15
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公开(公告)号： US20120264687A1公开(公告)日： 2012-10-18
- 发明人: Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
- 申请人： Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
- 申请人地址： JP Osaka-shi, Osaka
- 专利权人： Kaneka Corporation
- 当前专利权人： Kaneka Corporation
- 当前专利权人地址： JP Osaka-shi, Osaka
- 优先权： JP2009-213205 20090915
- 国际申请： PCT/JP2010/065976 WO 20100915
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; A61P7/06
摘要：
An object of the invention is to provide a pharmaceutical composition that contains erythropoietin as the active ingredient and has, when administered in humans and/or animals, a hematopoietic effect that lasts for not less than seven days. The invention provides a pharmaceutical composition containing, in an amount equal to not less than 50% of the total erythropoietin, erythropoietin to which two or more water-soluble long-chain molecules are added. The invention also provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a molecular weight of not less than 30 kDa. The invention further provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a branched chain.