公开(公告)号：US20120264687A1

公开(公告)日：2012-10-18

申请号：US13395534

申请日：2010-09-15

申请人： Nobutaka Tani ,  Toshihide Fujii ,  Hiroyuki Watanabe ,  Hirofumi Maeda

发明人： Nobutaka Tani ,  Toshihide Fujii ,  Hiroyuki Watanabe ,  Hirofumi Maeda

IPC分类号： A61K38/18 ,  A61P7/06

CPC分类号： A61K9/0019 ,  A61K38/1816 ,  A61K47/60

摘要： An object of the invention is to provide a pharmaceutical composition that contains erythropoietin as the active ingredient and has, when administered in humans and/or animals, a hematopoietic effect that lasts for not less than seven days. The invention provides a pharmaceutical composition containing, in an amount equal to not less than 50% of the total erythropoietin, erythropoietin to which two or more water-soluble long-chain molecules are added. The invention also provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a molecular weight of not less than 30 kDa. The invention further provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a branched chain.

摘要翻译： 本发明的目的是提供一种含有促红细胞生成素作为活性成分并且在人和/或动物中施用时持续不少于7天的造血作用的药物组合物。 本发明提供一种药物组合物，其含量等于不少于总促红细胞生成素的50％，红细胞生成素，其中加入了两种或更多种水溶性长链分子。 本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中水溶性长链分子的分子量不小于30kDa。 本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中所述水溶性长链分子具有支链。

公开(公告)号：US20090029429A1

公开(公告)日：2009-01-29

申请号：US11573602

申请日：2005-08-04

申请人： Tatsuya Honda ,  Hirofumi Maeda ,  Nobuo Nagashima ,  Shigeru Kawano ,  Yoshihiko Yasohara

发明人： Tatsuya Honda ,  Hirofumi Maeda ,  Nobuo Nagashima ,  Shigeru Kawano ,  Yoshihiko Yasohara

IPC分类号： C12P7/40

CPC分类号： C07C59/90 ,  C07B2200/07 ,  C07C67/11 ,  C07C69/734 ,  C12P7/42 ,  C12P7/62 ,  Y02P20/55

摘要： The present invention relates to a process for producing an optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl)propionic acid derivative which comprises stereoselectively reducing an 2-oxo-3-(4-substituent-oxyphenyl)propionic acid by an enzyme and subjecting the thus-obtained optically active 2-hydroxy-3-(4-substituent-oxyphenyl)propionic acid to esterification of the carboxyl group according to need, then to alkylation of the hydroxyl group and, if necessary, to deprotection of an ether type protective group. The present invention may make it possible to produce an optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl)propionic acid derivative, which is useful as intermediates for the synthesis of medicinal compounds, efficiently, in a simple and easy manner, and commercially advantageously.

摘要翻译： 本发明涉及一种光学活性2-取代基 - 氧基-3-（4-取代基 - 氧基苯基）丙酸衍生物的制备方法，其包括立体选择性还原2-氧代-3-（4-取代基 - 苯氧基）丙酸 通过酶将由此获得的光学活性2-羟基-3-（4-取代基 - 氧基苯基）丙酸根据需要进行羧基酯化，然后进行羟基的烷基化，如果需要，进行脱保护 的醚类保护基。 本发明可以制备光学活性的2-取代基 - 氧基-3-（4-取代基 - 氧基苯基）丙酸衍生物，其有效地用于合成药用化合物的中间体，简单易行 方式和商业上有利地。

公开(公告)号：US4682989A

公开(公告)日：1987-07-28

申请号：US789672

申请日：1985-10-21

申请人： Hirofumi Maeda ,  Naruhiko Akamatsu

发明人： Hirofumi Maeda ,  Naruhiko Akamatsu

IPC分类号： C08J9/22 ,  C08J9/16 ,  C08J11/00 ,  C08J11/02 ,  B01D53/14

CPC分类号： C08J11/02 ,  Y10S264/09

摘要： The present invention provides a method of recovering volatile foaming agent contained in prefoamed beads of polyolefin resin characterized in that the volatile foaming agent contained in the prefoamed beads is recovered by bringing into contact with heated air prefoamed beads obtained by heating polyolefin resin beads containing the volatile foaming agent. According to the invented method it is possible to avoid not only aggravation of the working environments and atmospheric pollution but also risk of explosion etc. and, furthermore, material cost can be saved through reutilization of the recovered volatile foaming agent.

摘要翻译： 本发明提供一种回收包含在聚烯烃树脂的预发泡珠中的挥发性发泡剂的方法，其特征在于，通过与通过加热含有挥发性的聚烯烃树脂珠而获得的加热空气预开泡珠接触，回收预发泡珠中包含的挥发性发泡剂 发泡剂。 根据本发明的方法，不仅可以避免工作环境恶化和大气污染，而且可以避免爆炸等危险，此外，通过回收挥发性发泡剂的再利用可以节省材料成本。

公开(公告)号：US20100171891A1

公开(公告)日：2010-07-08

申请号：US12600800

申请日：2008-05-19

申请人： Toshiyuki Kaji ,  Gou Hirose ,  Takayuki Ohnishi ,  Hirofumi Maeda

发明人： Toshiyuki Kaji ,  Gou Hirose ,  Takayuki Ohnishi ,  Hirofumi Maeda

IPC分类号： G02F1/1335

CPC分类号： A63F13/2145 ,  A63F13/06 ,  A63F2300/1075 ,  G02F1/13338 ,  G02F1/133602 ,  G06F3/03545 ,  G06F3/046

摘要： Provided is a digitizer function-equipped liquid crystal display device capable of preventing the wire shadows of a loop antenna from being projected on a liquid crystal panel and capable of being applied to a large size liquid crystal panel. It is also possible to provide an information processing electronic device and a game device provided with the digitizer function-equipped liquid crystal display device. Here, the digitizer function-equipped liquid crystal display device includes: a liquid crystal panel 1; a light diffusion member 2 which is disposed between the liquid crystal panel 1 and a backlight 5 irradiating the liquid crystal panel 1 with light; an electromagnetic induction type loop antenna which is disposed at a portion apart from the light diffusion member 2 in the direction toward the backlight 5 by a predetermined spacing so as to detect a position on the plane of the liquid crystal panel 1 in one coordinate axis direction and another coordinate axis direction that intersects the one coordinate axis direction; and a spacing retaining means for retaining the spacing between the light diffusion member 2 and loop antenna at a predetermined spacing value. As the spacing retaining means, a first light transmitting member 3 formed of a plate material having a light transmitting property is used.

摘要翻译： 提供了一种能够防止环形天线的阴影投影在液晶面板上并能够应用于大尺寸液晶面板的具有数字化仪功能的液晶显示装置。 还可以提供一种信息处理电子装置和设置有数字化仪功能的液晶显示装置的游戏装置。 这里，具有数字化仪功能的液晶显示装置包括：液晶面板1; 配置在液晶面板1和用液晶面板1照射光的背光源5之间的光漫射构件2; 电磁感应型环形天线，其以与光扩散构件2隔开的方向配置在朝向背光源5的方向上预定的间隔，以便检测液晶面板1的一个坐标轴方向的平面上的位置 和与一个坐标轴方向相交的另一坐标轴方向; 以及用于以预定间隔值保持光漫射构件2和环形天线之间的间隔的间隔保持装置。 作为间隔保持机构，使用由具有透光性的板材形成的第一透光部件3。

公开(公告)号：US4968723A

公开(公告)日：1990-11-06

申请号：US257113

申请日：1988-10-13

申请人： Kenichi Senda ,  Masao Ando ,  Hirofumi Maeda

发明人： Kenichi Senda ,  Masao Ando ,  Hirofumi Maeda

IPC分类号： C08J9/22 ,  B29C44/44 ,  C08J9/16 ,  C08J9/228 ,  C08J9/232 ,  C08L23/02

CPC分类号： C08J9/232 ,  B29C44/445 ,  C08J9/228 ,  C08J2323/02

摘要： A pre-expanded particle of a non-crosslinked linear low density polyethylene having an average cell diameter as large as 120 to 1,200 .mu.m which can be molded, without further imparting an expandability prior to molding or without aging under pressure, by heating in a closed mold permeable to a fluid heating medium such as steam to form a well bonded unitary cellular molded article having a good appearance, a high expansion ratio and improved heat resistance and mechanical property with a slight volumetric shrinkage.

摘要翻译： 平均泡孔直径为120-1200μm的非交联线型低密度聚乙烯的预发泡颗粒，其可以模塑，而不会在模塑之前进一步赋予膨胀性，或在压力下不加老化，通过在 封闭的模具可以通过诸如蒸汽的流体加热介质渗透，以形成具有良好外观，高膨胀率和改善的耐热性以及具有轻微的体积收缩的机械性能的良好结合的单元的多孔模塑制品。

公开(公告)号：US4830798A

公开(公告)日：1989-05-16

申请号：US96582

申请日：1987-09-15

申请人： Hirofumi Maeda

发明人： Hirofumi Maeda

IPC分类号： B29C44/00 ,  B29C44/44 ,  B29K23/00 ,  B29K105/00 ,  C08J9/18 ,  C08J9/22 ,  C08J9/232 ,  C08L23/10

CPC分类号： C08J9/232 ,  B29C44/445 ,  C08J2323/10 ,  C08L23/10 ,  Y10S264/09 ,  Y10S264/16

摘要： The present invention provides that, in a process for production of foamed articles of a polyproplene resin which comprises compressing pre-expanded beads of propylene resins under a gaseous pressure, filling a mold capable of closing but incapable of sealing with the compressed beads, then venting from the mold and heating and fusing with steam thereby to produce the molded article in the shape of the mold, the improvement wherein the pre-expanded beads of the polypropylene resins having two melting points when measured by differential scanning calorimetry and having a quantity of the peak fusion heat QH based on a melting point at a high temperature peak of the two melting points being 0.3 to 3.5 cal/g are introduced compressively into the mold so that a compressive rate is 10 to 60%. According to the present invention, the foamed articles of polypropylene having a minimized dimensional shrinkage rate (good dimensional accuracy) and excellent fusion rate and surface appearance can be produced in high productivity.

摘要翻译： 本发明提供了在生产聚丙烯树脂发泡制品的方法中，其包括在气压下压缩丙烯树脂的预发泡珠粒，填充能够关闭但不能用压缩珠密封的模具，然后排气 从模具中加热并与蒸汽融合从而制成模具形状的模塑制品，改进之处在于，当通过差示扫描量热法测量时，具有两个熔点的聚丙烯树脂的预发泡珠粒具有两个熔点 基于两个熔点的高温峰值的熔点为0.3〜3.5cal / g的峰值熔融热QH被压缩地引入模具中，使得压缩率为10〜60％。 根据本发明，能够以高生产率制造具有最小尺寸收缩率（良好尺寸精度）和优异的熔融率和表面外观的聚丙烯泡沫制品。

公开(公告)号：US08252919B2

公开(公告)日：2012-08-28

申请号：US12919295

申请日：2009-02-26

申请人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

发明人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

IPC分类号： C07H23/00 ,  C07H19/00 ,  C07H19/167 ,  C07H19/173

CPC分类号： C07H19/067 ,  C07H19/167

摘要： The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating or a carbamoylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.

摘要翻译： 本发明涉及通过在由铜化合物和光学活性配体组成的金属络合物的存在下使核糖核苷与酰化剂或氨基甲酰化试剂反应来制备2'-羟基保护的核苷衍生物的方法。 通过本发明的方法，可以容易地制备作为制备寡核苷酸的重要中间体的2'-羟基保护的核糖核苷衍生物，其从2'，3'-羟基的核苷衍生物具有良好的区域选择性 没有保护。

公开(公告)号：US07223859B2

公开(公告)日：2007-05-29

申请号：US10801141

申请日：2004-03-16

申请人： Tatsuyoshi Tanaka ,  Masanobu Sugawara ,  Hirofumi Maeda ,  Akira Nishiyama ,  Yoshihiko Yasohara ,  Nobuo Nagashima

发明人： Tatsuyoshi Tanaka ,  Masanobu Sugawara ,  Hirofumi Maeda ,  Akira Nishiyama ,  Yoshihiko Yasohara ,  Nobuo Nagashima

IPC分类号： C07D205/02 ,  C07C233/00

CPC分类号： C07D205/08 ,  C07C231/02 ,  C07C309/66 ,  C07C309/73

摘要： The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products, particularly an inhibitor of a cholesteryl ester transfer protein (CETP) from easily available raw materials. In the present invention, (S)-N-[4-(trifluoromethyl)phenyl]-3-hydroxypentanoic acid amide prepared from easily available raw materials leads a production of (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone to give (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide. Furthermore, (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone is reacted with a carbamic acid ester to give an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative.

摘要翻译： 本发明提供了一种容易地制备用于药物产品中间体（特别是胆固醇酯转移蛋白（CETP）抑制剂）的（R）-3- [4-（三氟甲基）苯基氨基] - 戊酸酰胺衍生物的方法， 容易获得的原料。 在本发明中，由容易获得的原料制备的（S）-N- [4-（三氟甲基）苯基] -3-羟基戊酸酰胺导致（R）-4-乙基-1- [4-（三氟甲基） ）苯基] -2-氮杂环丁酮，得到（R）-3- [4-（三氟甲基）苯基氨基] - 戊酸酰胺。 此外，将（R）-4-乙基-1- [4-（三氟甲基）苯基] -2-氮杂环丁酮与氨基甲酸酯反应，得到（R）-3- [4-（三氟甲基）苯基氨基] - 戊酸 酰胺衍生物。

公开(公告)号：US4778829A

公开(公告)日：1988-10-18

申请号：US84058

申请日：1987-08-11

申请人： Tadayuki Ichimura ,  Kenichi Senda ,  Masao Ando ,  Hirofumi Maeda

发明人： Tadayuki Ichimura ,  Kenichi Senda ,  Masao Ando ,  Hirofumi Maeda

IPC分类号： B29C44/34 ,  C08J9/16 ,  C08J9/22 ,  C08J9/228 ,  C08J9/232

CPC分类号： C08J9/232 ,  B29C44/3461 ,  B29C44/445 ,  C08J9/228 ,  B29K2023/06 ,  B29K2995/0063 ,  C08J2323/02

摘要： A process for preparing pre-expanded particles of a thermoplastic resin, which comprises heating an aqueous dispersion of thermoplastic resin particles containing a volatile blowing agent to a high temperature under pressure in a pressure vessel, and releasing the dispersion into an atmosphere maintained at a lower pressure than the pressure in the pressure vessel and at a temperature of not lower than 40.degree. C. According to the process of the present invention, there can be obtained pre-expanded thermoplastic resin particles with a large average diameter of cells. By molding the pre-expanded particles obtained by the present invention, molded articles which are small in dimensional shrinkage and excellent in surface appearance can be obtained without imparting expandability to the particles or aging the particles under pressure prior to molding.

摘要翻译： 一种制备热塑性树脂预发泡颗粒的方法，包括在压力容器中将含有挥发性发泡剂的热塑性树脂颗粒的水分散体加热至高温，并将分散体释放到保持在较低温度 压力高于压力容器中的压力，并且温度不低于40℃。根据本发明的方法，可以获得具有较大平均直径的电池的预发泡热塑性树脂颗粒。 通过模制本发明获得的预发泡颗粒，可以获得尺寸收缩小和表面外观优异的模制品，而不会在模塑之前赋予颗粒的可扩展性或使压力下的颗粒老化。

公开(公告)号：US20100113842A1

公开(公告)日：2010-05-06

申请号：US12594577

申请日：2008-04-02

申请人： Hirofumi Maeda ,  Kenji Inoue ,  Takaji Matsumoto ,  Izuru Nagasaki ,  Ryoji Noyori ,  Susumu Saito

发明人： Hirofumi Maeda ,  Kenji Inoue ,  Takaji Matsumoto ,  Izuru Nagasaki ,  Ryoji Noyori ,  Susumu Saito

IPC分类号： C07C31/18 ,  C07C27/04

CPC分类号： C07B53/00 ,  C07B2200/07 ,  C07C29/157 ,  C07C213/00 ,  C07C231/12 ,  C07C269/06 ,  C07C31/20 ,  C07C33/20 ,  C07C31/207 ,  C07C31/22 ,  C07C31/205 ,  C07C33/22 ,  C07C33/26 ,  C07C215/28 ,  C07C233/73 ,  C07C271/16

摘要： Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic efficiency. This method also enables to produce an optically active alcohol from an optically active lactone or an optically active carboxylic acid ester. Specifically disclosed is a method for producing an alcohol by hydrogen reducing a lactone or a carboxylic acid ester in the presence of a catalyst containing ruthenium and a phosphine compound represented by the following general formula (1): wherein R1 represents a spacer; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group; and R8, R9, R10, R11, R12 and R13 independently represent an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group.

摘要翻译： 公开了一种从内酯或羧酸酯制备醇的方法，其能够在相对温和的条件下以高产率和高催化效率从内酯或羧酸酯制备醇。 该方法还能够从光学活性的内酯或光学活性的羧酸酯制备光学活性的醇。 具体公开的是通过在含有钌的催化剂和由以下通式（1）表示的膦化合物的存在下氢还原内酯或羧酸酯来制备醇的方法：其中R1表示间隔基; R2，R3，R4，R5，R6和R7独立地表示氢原子，具有1-12个碳原子的烷基，芳基或杂环基; 并且R 8，R 9，R 10，R 11，R 12和R 13独立地表示具有1-12个碳原子的烷基，芳基或杂环基。