发明申请
- 专利标题： OLIGOMERIC COMPOUNDS AND EXCIPIENTS
- 专利标题（中）： 低分子化合物和成分
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申请号： US13148291申请日： 2010-02-05
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公开(公告)号： US20120264806A1公开(公告)日： 2012-10-18
- 发明人: C. Frank Bennett , Richard S. Geary , Eric E. Swayze , Andrew M. Siwkowski
- 申请人： C. Frank Bennett , Richard S. Geary , Eric E. Swayze , Andrew M. Siwkowski
- 国际申请： PCT/US10/23383 WO 20100205
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61K31/713
摘要：
The present invention provides method of optimizing the efficacy and potency of antisense compounds. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.
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