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公开(公告)号：US20120264806A1
公开(公告)日：2012-10-18
申请号：US13148291
申请日：2010-02-05
IPC分类号： A61K31/7088 , A61K31/713
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/7088 , A61K31/721 , A61K47/36 , C12N15/111 , C12N2310/11 , C12N2320/30 , C12N2320/32
摘要： The present invention provides method of optimizing the efficacy and potency of antisense compounds. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.
摘要翻译： 本发明提供了优化反义化合物的功效和效力的方法。 在某些实施方案中，本发明提供可用于确定有利的寡核苷酸特征的测定和用于改善细胞摄取的赋形
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公开(公告)号：US07745609B2
公开(公告)日：2010-06-29
申请号：US11466369
申请日：2006-08-22
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , B01J2219/007 , C07K14/003 , C12N15/1048 , C12N2310/11 , C12N2310/3181 , C12N2310/321 , C12N2310/3513 , C12N2310/52 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD40. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40. Methods of using these compounds for modulation of CD40 expression and for treatment of diseases associated with CD40 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节CD40的表达。 组合物包含靶向编码CD40的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节CD40表达和治疗与CD40相关疾病的方法。
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公开(公告)号：US09006198B2
公开(公告)日：2015-04-14
申请号：US13577622
申请日：2011-02-08
申请人： C. Frank Bennett , Michael Hayden , Susan M. Freier , Sarah Greenlee , Jeffrey Carroll , Simon Warby , Eric E. Swayze
发明人： C. Frank Bennett , Michael Hayden , Susan M. Freier , Sarah Greenlee , Jeffrey Carroll , Simon Warby , Eric E. Swayze
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6883 , C12N15/113 , C12N2310/11 , C12N2320/34 , C12Q1/6811 , C12Q1/6897 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2525/207 , C12Q2535/131 , C12Q2539/107 , C12Q2521/327 , C12Q2525/121 , C12Q2525/185
摘要： Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a huntingtin gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate Huntington's Disease (HD).
摘要翻译： 本文公开了用于选择性降低含有单核苷酸多态性（SNP）的亨廷顿氏基因的等位变体的表达的反义化合物和方法。 这些方法，化合物和组合物可用于治疗，预防或改善亨廷顿病（HD）。
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公开(公告)号：US08957040B2
公开(公告)日：2015-02-17
申请号：US13577616
申请日：2011-02-08
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/34
摘要： Disclosed herein are antisense compounds and methods for selectively of reducing expression of an allelic variant of a gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate diseases, including neurodegenerative, such as Huntington's Disease (HD).
摘要翻译： 本文公开了用于选择性降低含有单核苷酸多态性（SNP）的基因的等位变体的表达的反义化合物和方法。 这些方法，化合物和组合物可用于治疗，预防或改善疾病，包括神经变性如亨廷顿病（HD）。
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5.发明申请OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS 有权用于调节小型非编码RNAs的低分子化合物和组合物公开(公告)号：US20120122216A1
公开(公告)日：2012-05-17
申请号：US13359271
申请日：2012-01-26
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： C12N5/071
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。
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公开(公告)号：US20090317907A1
公开(公告)日：2009-12-24
申请号：US12345725
申请日：2008-12-30
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： C12N5/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
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公开(公告)号：US06335194B1
公开(公告)日：2002-01-01
申请号：US09496694
申请日：2000-02-02
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C07B2200/11 , C07H21/00 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节存活蛋白的表达。 组合物包含靶向编码存活蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活蛋白表达相关的疾病的方法。
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8.发明授权Oligomeric compounds and compositions for use in modulation of small non-coding RNAs 失效用于调节小非编码RNA的低聚化合物和组合物公开(公告)号：US07683036B2
公开(公告)日：2010-03-23
申请号：US10909125
申请日：2004-07-30
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。
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9.发明申请Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs 有权用于调节小非编码RNA的低聚化合物和组合物公开(公告)号：US20090291907A1
公开(公告)日：2009-11-26
申请号：US12345891
申请日：2008-12-30
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： A61K31/7105 , C12N5/06 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。
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公开(公告)号：US6165788A
公开(公告)日：2000-12-26
申请号：US286407
申请日：1999-04-05
IPC分类号： C07H21/04 , A61K31/7088 , A61K31/712 , A61K48/00 , A61P35/00 , C07H21/00 , C12P21/04 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07B2200/11
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
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